C3;C-Snap25^Bdr/H

Status	Available to order
EMMA ID	EM:01844
International strain name	C3;C-Snap25^Bdr/H
Alternative name	GENA70
Strain type	Induced Mutant Strains : Chemically-induced
Allele/Transgene symbol	Snap25^Bdr
Gene/Transgene symbol	Snap25

Information from provider

Provider	Pat Nolan
Provider affiliation	MRC Mammalian Genetics Unit
Genetic information	Point mutation resulting in a subtle ataxic gait from weaning age, 10-20% smaller than littermates
Phenotypic information	Homozygous mutants die at P1, heterozygous mutants show subtle ataxic gait from weaning age, 10-20% smaller than littermates
References	A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191 A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse.;Jeans Alexander F, Oliver Peter L, Johnson Reuben, Capogna Marco, Vikman Jenny, Molnár Zoltán, Babbs Arran, Partridge Christopher J, Salehi Albert, Bengtsson Martin, Eliasson Lena, Rorsman Patrik, Davies Kay E, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;2431-6; 17283335

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

schizophrenia / DOID:5419

Orphanet associated rare diseases, based on orthologous gene matching

Presynaptic congenital myasthenic syndromes / Orphanet_98914

MGI phenotypes (allele matching)

abnormal motor capabilities/coordination/movement / MGI
ataxia / MGI
impaired coordination / MGI
decreased glucagon secretion / MGI
decreased insulin secretion / MGI
abnormal pancreatic beta cell physiology / MGI
decreased synaptic glutamate release / MGI
abnormal miniature excitatory postsynaptic currents / MGI
behavior/neurological phenotype / MGI
taste/olfaction phenotype / MGI
decreased prepulse inhibition / MGI

MGI phenotypes (gene matching)

increased white adipose tissue amount / MGI
myoclonus / MGI
tremors / MGI
thin diaphragm muscle / MGI
abnormal cerebral cortex morphology / MGI
convulsive seizures / MGI
abnormal skin condition / MGI
increased body weight / MGI
decreased body weight / MGI
decreased body size / MGI
delayed eyelid opening / MGI
increased anxiety-related response / MGI
abnormal locomotor behavior / MGI
ataxia / MGI
hyperactivity / MGI
hypoactivity / MGI
no spontaneous movement / MGI
impaired coordination / MGI
abnormal object recognition memory / MGI
abnormal spatial learning / MGI
unresponsive to tactile stimuli / MGI
disheveled coat / MGI
increased circulating triglyceride level / MGI
hyperglycemia / MGI
abnormal blood vessel morphology / MGI
decreased embryo size / MGI
abnormal dopamine level / MGI
infertility / MGI
respiratory failure / MGI
seizures / MGI
abnormal motor capabilities/coordination/movement / MGI
increased circulating insulin level / MGI
premature death / MGI
abnormal brain morphology / MGI
no abnormal phenotype detected / MGI
abnormal CNS synaptic transmission / MGI
abnormal intercostal muscle morphology / MGI
hepatic steatosis / MGI
akinesia / MGI
decreased glucagon secretion / MGI
decreased vertical activity / MGI
increased thigmotaxis / MGI
blotchy skin / MGI
abnormal PNS synaptic transmission / MGI
abnormal endplate potential / MGI
enhanced paired-pulse facilitation / MGI
decreased paired-pulse facilitation / MGI
no phenotypic analysis / MGI
decreased insulin secretion / MGI
decreased width of hypertrophic chondrocyte zone / MGI
abnormal pancreatic beta cell physiology / MGI
abnormal insulin secretion / MGI
decreased synaptic glutamate release / MGI
abnormal miniature excitatory postsynaptic currents / MGI
increased circulating cholesterol level / MGI
improved glucose tolerance / MGI
abnormal serotonin level / MGI
insulin resistance / MGI
behavior/neurological phenotype / MGI
taste/olfaction phenotype / MGI
increased susceptibility to diet-induced obesity / MGI
increased circulating leptin level / MGI
increased body mass index / MGI
impaired hearing / MGI
abnormal hippocampus CA3 region morphology / MGI
increased white fat cell size / MGI
decreased prepulse inhibition / MGI
abnormal impulsive behavior control / MGI
postnatal lethality, incomplete penetrance / MGI
neonatal lethality, complete penetrance / MGI
decreased circulating ghrelin level / MGI
increased food intake / MGI
decreased food intake / MGI

Literature references

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191
A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse.;Jeans Alexander F, Oliver Peter L, Johnson Reuben, Capogna Marco, Vikman Jenny, Molnár Zoltán, Babbs Arran, Partridge Christopher J, Salehi Albert, Bengtsson Martin, Eliasson Lena, Rorsman Patrik, Davies Kay E, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;2431-6; 17283335

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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C3;C-Snap25Bdr/H