IMPC phenotypes (gene matching)
C3;C-GckGena348/H
| Status | Available to order |
| EMMA ID | EM:01842 |
| International strain name | C3;C-GckGena348/H |
| Alternative name | Gck |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | GckGena348 |
| Gene/Transgene symbol | Gck |
Information from provider
| Provider | Roger Cox |
| Provider affiliation | MRC Harwell, Didcot, Oxon |
| Genetic information | Impaired glucose tolerance in males and females |
| Phenotypic information | High blood glucose and increased body weight |
| References |
|
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Hyperinsulinism due to glucokinase deficiency / Orphanet_79299
- MODY / Orphanet_552
- Permanent neonatal diabetes mellitus / Orphanet_99885
MGI phenotypes (gene matching)
- abnormal circulating cholesterol level / MGI
- hypoglycemia / MGI
- increased body weight / MGI
- decreased body weight / MGI
- increased circulating triglyceride level / MGI
- increased circulating free fatty acid level / MGI
- hyperglycemia / MGI
- abnormal circulating insulin level / MGI
- postnatal growth retardation / MGI
- increased urine glucose level / MGI
- abnormal glucose homeostasis / MGI
- increased circulating insulin level / MGI
- postnatal lethality / MGI
- increased circulating ketone body level / MGI
- hepatic steatosis / MGI
- decreased circulating insulin level / MGI
- decreased insulin secretion / MGI
- abnormal pancreatic beta cell physiology / MGI
- abnormal insulin secretion / MGI
- abnormal pancreatic islet morphology / MGI
- abnormal pancreatic beta cell morphology / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- homeostasis/metabolism phenotype / MGI
- endocrine/exocrine gland phenotype / MGI
- decreased glycogen level / MGI
- increased circulating glucose level / MGI
- decreased circulating glucose level / MGI
- increased glycosylated hemoglobin level / MGI
- decreased pancreatic beta cell mass / MGI
- small pancreatic islets / MGI
- mortality/aging / MGI
- postnatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- decreased glucokinase activity / MGI
Literature references
- A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191
- A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene.;Toye Ayo A, Moir Lee, Hugill Alison, Bentley Liz, Quarterman Julie, Mijat Vesna, Hough Tertius, Goldsworthy Michelle, Haynes Alison, Hunter A Jacqueline, Browne Mick, Spurr Nigel, Cox Roger D, ;2004;Diabetes;53;1577-83; 15161764