IMPC phenotypes (gene matching)
C3;C-GckGena348/H
| Status | Available to order |
| EMMA ID | EM:01842 |
| Citation information | RRID:IMSR_EM:01842 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3;C-GckGena348/H |
| Alternative name | Gck |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | GckGena348 |
| Gene/Transgene symbol | Gck |
Information from provider
| Provider | Roger Cox |
| Provider affiliation | MRC Harwell, Didcot, Oxon |
| Genetic information | Impaired glucose tolerance in males and females |
| Phenotypic information | High blood glucose and increased body weight |
| References |
|
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Hyperinsulinism due to glucokinase deficiency / Orphanet_79299
- MODY / Orphanet_552
- Permanent neonatal diabetes mellitus / Orphanet_99885
MGI phenotypes (gene matching)
- abnormal circulating cholesterol level / MGI
- hypoglycemia / MGI
- increased body weight / MGI
- decreased body weight / MGI
- increased circulating triglyceride level / MGI
- increased circulating free fatty acid level / MGI
- hyperglycemia / MGI
- abnormal circulating insulin level / MGI
- postnatal growth retardation / MGI
- increased urine glucose level / MGI
- abnormal glucose homeostasis / MGI
- increased circulating insulin level / MGI
- postnatal lethality / MGI
- increased circulating ketone body level / MGI
- hepatic steatosis / MGI
- decreased circulating insulin level / MGI
- decreased insulin secretion / MGI
- abnormal pancreatic beta cell physiology / MGI
- abnormal insulin secretion / MGI
- abnormal pancreatic islet morphology / MGI
- abnormal pancreatic beta cell morphology / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- homeostasis/metabolism phenotype / MGI
- endocrine/exocrine gland phenotype / MGI
- decreased glycogen level / MGI
- increased circulating glucose level / MGI
- decreased circulating glucose level / MGI
- increased glycosylated hemoglobin level / MGI
- decreased pancreatic beta cell mass / MGI
- small pancreatic islets / MGI
- mortality/aging / MGI
- postnatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- decreased glucokinase activity / MGI
Literature references
- A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191
- A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene.;Toye Ayo A, Moir Lee, Hugill Alison, Bentley Liz, Quarterman Julie, Mijat Vesna, Hough Tertius, Goldsworthy Michelle, Haynes Alison, Hunter A Jacqueline, Browne Mick, Spurr Nigel, Cox Roger D, ;2004;Diabetes;53;1577-83; 15161764