B6.129-Foxe1tm1Rdl/Cnrm

Status

Available to order

EMMA IDEM:00183
Citation informationRRID:IMSR_EM:00183 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.129-Foxe1tm1Rdl/Cnrm
Alternative nameTitf2-KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolFoxe1tm1Rdl
Gene/Transgene symbolFoxe1

Information from provider

ProviderRoberto Di Lauro
Provider affiliationStaz. Zoologica-Napoli
Genetic informationA neo-resistance cassette was inserted into the coding region of Foxe1 (or Titf2).
Phenotypic informationAthyreosis, cleft palate. Model for cleft palate and congenital hypothyroidism.
References
  • A mouse model for hereditary thyroid dysgenesis and cleft palate.;De Felice M, Ovitt C, Biffali E, Rodriguez-Mallon A, Arra C, Anastassiadis K, Macchia P E, Mattei M G, Mariano A, Schöler H, Macchia V, Di Lauro R, ;1998;Nature genetics;19;395-8; 9697704

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal thyroid gland development / MGI
  • cleft palate / MGI
  • abnormal hair follicle orientation / MGI
  • increased curvature of hairs / MGI
  • waved hair / MGI
  • sparse hair / MGI
  • abnormal coat appearance / MGI
  • decreased circulating levels of thyroid hormone / MGI
  • abnormal hair shaft morphology / MGI
  • increased circulating thyroid-stimulating hormone level / MGI
  • absent thyroid gland / MGI
  • palatal shelves fail to meet at midline / MGI
  • postnatal lethality, complete penetrance / MGI
MGI phenotypes (gene matching)
  • cleft palate / MGI
  • abnormal hair follicle orientation / MGI
  • increased curvature of hairs / MGI
  • waved hair / MGI
  • sparse hair / MGI
  • abnormal coat appearance / MGI
  • decreased circulating levels of thyroid hormone / MGI
  • abnormal thyroid gland development / MGI
  • abnormal hair shaft morphology / MGI
  • increased circulating thyroid-stimulating hormone level / MGI
  • absent thyroid gland / MGI
  • palatal shelves fail to meet at midline / MGI
  • postnatal lethality, complete penetrance / MGI

Literature references

  • A mouse model for hereditary thyroid dysgenesis and cleft palate.;De Felice M, Ovitt C, Biffali E, Rodriguez-Mallon A, Arra C, Anastassiadis K, Macchia P E, Mattei M G, Mariano A, Schöler H, Macchia V, Di Lauro R, ;1998;Nature genetics;19;395-8; 9697704

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).