IMPC phenotypes (gene matching)
129S2-Otogtm1Prs/Orl
| Status | Available to order |
| EMMA ID | EM:01821 |
| Citation information | RRID:IMSR_EM:01821 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129S2-Otogtm1Prs/Orl |
| Alternative name | Otog |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Otogtm1Prs |
| Gene/Transgene symbol | Otog |
Information from provider
| Provider | SIMMLER MARIE-CHRISTINE |
| Provider affiliation | Institut Jacques-Monod, CNRS, Equipe labellisée INSERM U950 |
| Genetic information | To inactivate the Otog gene the first three exons were removed and replaced with the lacZ gene fused in-frame with the Otog translation initiation codon. |
| Phenotypic information | In Otog -/- mice, both vestibular and auditory functions were impaired. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive non-syndromic sensorineural deafness type DFNB / Orphanet_90636
MGI phenotypes (allele matching)
- abnormal cochlea morphology / MGI
- circling / MGI
- abnormal posture / MGI
- impaired swimming / MGI
- impaired righting response / MGI
- impaired balance / MGI
- abnormal semicircular canal morphology / MGI
- detached otolithic membrane / MGI
- abnormal tectorial membrane morphology / MGI
- abnormal crista ampullaris morphology / MGI
- head tilt / MGI
- abnormal vestibular saccule morphology / MGI
- abnormal utricle morphology / MGI
- impaired hearing / MGI
- absent pinna reflex / MGI
- increased or absent threshold for auditory brainstem response / MGI
MGI phenotypes (gene matching)
- abnormal cochlea morphology / MGI
- circling / MGI
- hyperactivity / MGI
- impaired coordination / MGI
- abnormal pinna reflex / MGI
- abnormal posture / MGI
- impaired swimming / MGI
- impaired righting response / MGI
- impaired balance / MGI
- abnormal placing response / MGI
- reduced fertility / MGI
- deafness / MGI
- abnormal semicircular canal morphology / MGI
- abnormal otolith morphology / MGI
- abnormal otolithic membrane morphology / MGI
- detached otolithic membrane / MGI
- abnormal tectorial membrane morphology / MGI
- abnormal ear physiology / MGI
- abnormal crista ampullaris morphology / MGI
- abnormal vestibular saccular macula morphology / MGI
- decreased vestibular hair cell stereocilia number / MGI
- head tilt / MGI
- abnormal vestibular saccule morphology / MGI
- abnormal utricle morphology / MGI
- impaired hearing / MGI
- nonsyndromic hearing impairment / MGI
- absent pinna reflex / MGI
- absent startle reflex / MGI
- increased or absent threshold for auditory brainstem response / MGI
Literature references
- Twister mutant mice are defective for otogelin, a component specific to inner ear acellular membranes;Simmler MC, Zwaenepoel I, Verpy E, Guillaud L, Elbaz C, Petit C, Panthier JJ;2000;Mammalian genome : official journal of the International Mammalian Genome Society;11;960-6; 11063250
- Targeted disruption of otog results in deafness and severe imbalance.;Simmler M C, Cohen-Salmon M, El-Amraoui A, Guillaud L, Benichou J C, Petit C, Panthier J J, ;2000;Nature genetics;24;139-43; 10655058