B6.Cg-Tg(SERPINA1-IGHG1/Il1rl1)423Zbz/ZbzCnrm

Status	Available to order
EMMA ID	EM:00182
Citation information	RRID:IMSR_EM:00182 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.Cg-Tg(SERPINA1-IGHG1/Il1rl1)423Zbz/ZbzCnrm
Alternative name	TgN423AAT-T1FcZbz
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(SERPINA1-IGHG1/Il1rl1)423Zbz
Gene/Transgene symbol	Tg(SERPINA1-IGHG1/Il1rl1)423Zbz

Information from provider

Provider	Karin Senn
Provider affiliation	Institute of Experimental Immunology, Institute of Experimental Immunology
Genetic information	Overexpression of interleukin 1 receptor-like 1 (Il1rl1 or T1/ST2) protein under liver-specific SERPINA1 (a1-antitrypsin) promoter. This strain was generated in the attempt to scavenge the putative T1 ligand and thereby prevent its interaction with the T1/ST2 receptor on mast and Th2 cells.
Phenotypic information	The Il1rl1 (or T1/ST2) receptor is expressed on mast and Th2 cells; both cell types show no defect so far. Further studies using different infectious models are ongoing.
References	T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis.;Senn K A, McCoy K D, Maloy K J, Stark G, Fröhli E, Rülicke T, Klemenz R, ;2000;European journal of immunology;30;1929-38; 10940882

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Literature references

T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis.;Senn K A, McCoy K D, Maloy K J, Stark G, Fröhli E, Rülicke T, Klemenz R, ;2000;European journal of immunology;30;1929-38; 10940882
Durable lymphocyte subset elimination upon a single dose of AAV-delivered depletion antibody dissects immune control of chronic viral infection.;Kastner Anna Lena, Marx Anna-Friederike, Dimitrova Mirela, Abreu-Mota Tiago, Ertuna Yusuf I, Bonilla Weldy V, Stauffer Karsten, Künzli Marco, Wagner Ingrid, Kreutzfeldt Mario, Merkler Doron, Pinschewer Daniel D, ;2025;Immunity;58;481-498.e10; 39719711

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
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Material Transfer Agreement (MTA)
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