B6.Cg-Tg(SERPINA1-IGHG1/Il1rl1)423Zbz/ZbzCnrm
Status | Available to order |
EMMA ID | EM:00182 |
International strain name | B6.Cg-Tg(SERPINA1-IGHG1/Il1rl1)423Zbz/ZbzCnrm |
Alternative name | TgN423AAT-T1FcZbz |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(SERPINA1-IGHG1/Il1rl1)423Zbz |
Gene/Transgene symbol | Tg(SERPINA1-IGHG1/Il1rl1)423Zbz |
Information from provider
Provider | Karin Senn |
Provider affiliation | Institute of Experimental Immunology, Institute of Experimental Immunology |
Genetic information | Overexpression of interleukin 1 receptor-like 1 (Il1rl1 or T1/ST2) protein under liver-specific SERPINA1 (a1-antitrypsin) promoter. This strain was generated in the attempt to scavenge the putative T1 ligand and thereby prevent its interaction with the T1/ST2 receptor on mast and Th2 cells. |
Phenotypic information | The Il1rl1 (or T1/ST2) receptor is expressed on mast and Th2 cells; both cell types show no defect so far. Further studies using different infectious models are ongoing. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis.;Senn K A, McCoy K D, Maloy K J, Stark G, Fröhli E, Rülicke T, Klemenz R, ;2000;European journal of immunology;30;1929-38; 10940882
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