IMPC phenotypes (gene matching)
- abnormal kidney morphology / IMPC
B6.129S2-Lime1tm1Mal/Orl
| Status | Available to order |
| EMMA ID | EM:01815 |
| Citation information | RRID:IMSR_EM:01815 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S2-Lime1tm1Mal/Orl |
| Alternative name | LIME KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Lime1tm1Mal |
| Gene/Transgene symbol | Lime1 |
Information from provider
| Provider | Malissen Marie |
| Provider affiliation | Centre d'Immunologi de Marseille Luminy |
| Genetic information | Complete knock-out with deletion of exons 1-5. Deletion was obtained by the introduction of a loxP-neo cassette which was subsequently removed by crossing with cre recombinase deleter mice. |
| Phenotypic information | Lime1 (or Lime, Lck interacting molecule) is predominantly expressed in T lymphocytes. Lime becomes phosphorylated after coreceptors cross-linking. Lime appears to be involved in regulation of T cell activation by coreceptors. The Lime1 knock-out mutation does not prevent normal development and activation of lymphocytes. |
| Breeding history | This strain was first crossed onto a cre-deleter strain, followed by 8 backcrosses to C57BL/6. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Literature references
- LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.;Brdicková Nadezda, Brdicka Tomás, Angelisová Pavla, Horváth Ondrej, Spicka Jiri, Hilgert Ivan, Paces Jan, Simeoni Luca, Kliche Stefanie, Merten Camilla, Schraven Burkhart, Horejsí Václav, ;2003;The Journal of experimental medicine;198;1453-62; 14610046
- LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation.;Ahn Eunseon, Lee Hyunsook, Yun Yungdae, ;2006;Blood;107;1521-7; 16249387
- LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation.;Hur Eun Mi, Son Myoungsun, Lee Ok-Hee, Choi Young Bong, Park Changwon, Lee Hyunsook, Yun Yungdae, ;2003;The Journal of experimental medicine;198;1463-73; 14610044
- Deletion of the LIME adaptor protein minimally affects T and B cell development and function.;Grégoire Claude, Simova Sarka, Wang Ying, Sansoni Amandine, Richelme Sylvie, Schmidt-Giese Anja, Simeoni Luca, Angelisova Pavla, Reinhold Dirk, Schraven Burkhart, Horejsi Vaclav, Malissen Bernard, Malissen Marie, ;2007;European journal of immunology;37;3259-69; 17918199