B6;129P2-Prmt2tm1Yah Col6a1tm1Yah/+ +/Orl

Status

Available to order

EMMA IDEM:01809
International strain nameB6;129P2-Prmt2tm1Yah Col6a1tm1Yah/+ +/Orl
Alternative nameCis (Hrmt1l1tm1Yah-Col6a1tm1Ya
Strain typeTargeted Mutant Strains : Other targeted
Allele/Transgene symbolPrmt2tm1Yah, Col6a1tm1Yah
Gene/Transgene symbolPrmt2, Col6a1

Information from provider

ProviderYann HERAULT
Provider affiliationTAAM-CDTA UPS44, Institut de Transgenose, INTRAGENE
Genetic informationInsertion by homologous recombination in ES cells using MICER of a targeting vector containing a loxP site at the Hrmt1l1 (Prmt2) locus and of a second vector, on the same homologous chromosome, containing a loxP site at the Col6a1 locus (the two loxP sites are inserted in a cis configuration on MMU10).
Phenotypic informationNo visible phenotype.
Breeding historyThe mutation was generated in 129P2 ES cells, which were injected into C57BL/6 blastocysts. Backcrossed to C57BL/6 (N3) and then intercrossed.
References
  • Modeling the monosomy for the telomeric part of human chromosome 21 reveals haploinsufficient genes modulating the inflammatory and airway responses.;Besson Vanessa, Brault Véronique, Duchon Arnaud, Togbe Dieudonné, Bizot Jean-Charles, Quesniaux Valérie F J, Ryffel Bernard, Hérault Yann, ;2007;Human molecular genetics;16;2040-52; 17591625
  • Inducing segmental aneuploid mosaicism in the mouse through targeted asymmetric sister chromatid event of recombination.;Duchon Arnaud, Besson Vanessa, Pereira Patricia Lopes, Magnol Laetitia, Hérault Yann, ;2008;Genetics;180;51-9; 18757940

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • myopathy / MGI
  • abnormal skeletal muscle morphology / MGI
  • abnormal muscle morphology / MGI
  • abnormal diaphragm morphology / MGI
  • abnormal intercostal muscle morphology / MGI
  • impaired skeletal muscle contractility / MGI
  • skeletal muscle necrosis / MGI
  • muscle phenotype / MGI
  • centrally nucleated skeletal muscle fibers / MGI
  • abnormal cell cycle / MGI
  • abnormal vascular wound healing / MGI
  • increased sacral vertebrae number / MGI

Literature references

  • Modeling the monosomy for the telomeric part of human chromosome 21 reveals haploinsufficient genes modulating the inflammatory and airway responses.;Besson Vanessa, Brault Véronique, Duchon Arnaud, Togbe Dieudonné, Bizot Jean-Charles, Quesniaux Valérie F J, Ryffel Bernard, Hérault Yann, ;2007;Human molecular genetics;16;2040-52; 17591625
  • Inducing segmental aneuploid mosaicism in the mouse through targeted asymmetric sister chromatid event of recombination.;Duchon Arnaud, Besson Vanessa, Pereira Patricia Lopes, Magnol Laetitia, Hérault Yann, ;2008;Genetics;180;51-9; 18757940

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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