B6.129P2(SJL)-Del(10Prmt2-Col6a1)1Yah/Orl

Status

Available to order

EMMA IDEM:01808
International strain nameB6.129P2(SJL)-Del(10Prmt2-Col6a1)1Yah/Orl
Alternative nameDel(Hrmt1l1-Col6a1)Ms1Yah
Strain typeTargeted Mutant Strains : Other targeted
Allele/Transgene symbolDel(10Prmt2-Col6a1)1Yah
Gene/Transgene symbolDel(10Prmt2-Col6a1)1Yah

Information from provider

ProviderYann HERAULT
Provider affiliationTAAM-CDTA UPS44, Institut de Transgenose, INTRAGENE
Genetic informationDeletion of the region between the Hrmt1l1 (Prmt2) and Col6a1 genes engineered using Mutagenic Insertion and Chromosome Engineering Resource (MICER) in ES (HM1) cells.
Phenotypic informationHomozygotes: early embryonic lethal. Heterozygotes: no major defects.
Breeding historyDeletion generated in 129P2 HM1 ES cells. Cells injected in C57BL/6 blastocysts. Backcrossed to C57BL/6 (N7).
References
  • Modeling the monosomy for the telomeric part of human chromosome 21 reveals haploinsufficient genes modulating the inflammatory and airway responses.;Besson Vanessa, Brault Véronique, Duchon Arnaud, Togbe Dieudonné, Bizot Jean-Charles, Quesniaux Valérie F J, Ryffel Bernard, Hérault Yann, ;2007;Human molecular genetics;16;2040-52; 17591625
  • Rodent models in Down syndrome research: impact and future opportunities.;Herault Yann, Delabar Jean M, Fisher Elizabeth M C, Tybulewicz Victor L J, Yu Eugene, Brault Veronique, ;2017;Disease models & mechanisms;10;1165-1186; 28993310

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased hematocrit / MGI
  • lung inflammation / MGI
  • abnormal respiratory system physiology / MGI
  • respiratory system inflammation / MGI
  • abnormal macrophage physiology / MGI
  • growth/size/body region phenotype / MGI
  • behavior/neurological phenotype / MGI
  • abnormal cytokine level / MGI
  • increased red blood cell distribution width / MGI
MGI phenotypes (gene matching)
  • decreased hematocrit / MGI
  • lung inflammation / MGI
  • abnormal respiratory system physiology / MGI
  • respiratory system inflammation / MGI
  • abnormal macrophage physiology / MGI
  • growth/size/body region phenotype / MGI
  • behavior/neurological phenotype / MGI
  • abnormal cytokine level / MGI
  • increased red blood cell distribution width / MGI

Literature references

  • Modeling the monosomy for the telomeric part of human chromosome 21 reveals haploinsufficient genes modulating the inflammatory and airway responses.;Besson Vanessa, Brault Véronique, Duchon Arnaud, Togbe Dieudonné, Bizot Jean-Charles, Quesniaux Valérie F J, Ryffel Bernard, Hérault Yann, ;2007;Human molecular genetics;16;2040-52; 17591625
  • Rodent models in Down syndrome research: impact and future opportunities.;Herault Yann, Delabar Jean M, Fisher Elizabeth M C, Tybulewicz Victor L J, Yu Eugene, Brault Veronique, ;2017;Disease models & mechanisms;10;1165-1186; 28993310

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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