IMPC phenotypes (gene matching)
NOD.129S6-Cd1d1tm1Luc/Orl
| Status | Available to order |
| EMMA ID | EM:01803 |
| International strain name | NOD.129S6-Cd1d1tm1Luc/Orl |
| Alternative name | NOD CD1d KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cd1d1tm1Luc |
| Gene/Transgene symbol | Cd1d1 |
Information from provider
| Provider | Thieblemont Nathalie |
| Provider affiliation | CNRS UMR 8147 |
| Genetic information | A 200 bp sequence in the third exon of the Cd1d1 gene was replaced by a neomycin resistance cassette. |
| Phenotypic information | Absence of natural killer T cells. |
| References |
|
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
- autoimmune response / MGI
- decreased regulatory T cell number / MGI
- kidney inflammation / MGI
- glomerulonephritis / MGI
- increased urine protein level / MGI
- renal interstitial fibrosis / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- glomerulosclerosis / MGI
- increased blood urea nitrogen level / MGI
- increased IgG3 level / MGI
- decreased interleukin-4 secretion / MGI
- renal tubule atrophy / MGI
- glomerular crescent / MGI
- abnormal liver morphology / MGI
- arrested T cell differentiation / MGI
- decreased acute inflammation / MGI
- decreased NK T cell number / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-gamma secretion / MGI
- decreased physiological sensitivity to xenobiotic / MGI
MGI phenotypes (gene matching)
- abnormal liver morphology / MGI
- decreased IgG level / MGI
- arrested T cell differentiation / MGI
- abnormal T cell activation / MGI
- abnormal antigen presentation / MGI
- autoimmune response / MGI
- kidney inflammation / MGI
- lung inflammation / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal dendritic cell antigen presentation / MGI
- glomerulonephritis / MGI
- increased urine protein level / MGI
- increased susceptibility to ischemic brain injury / MGI
- renal interstitial fibrosis / MGI
- decreased susceptibility to induced arthritis / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- decreased regulatory T cell number / MGI
- decreased acute inflammation / MGI
- glomerulosclerosis / MGI
- increased blood urea nitrogen level / MGI
- abnormal NK T cell morphology / MGI
- decreased NK T cell number / MGI
- abnormal NK T cell physiology / MGI
- abnormal CD4-positive T cell differentiation / MGI
- increased IgG3 level / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-gamma secretion / MGI
- decreased interleukin-2 secretion / MGI
- abnormal interleukin-4 secretion / MGI
- decreased interleukin-4 secretion / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- renal tubule atrophy / MGI
- glomerular crescent / MGI
Literature references
- CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4.;Mendiratta S K, Martin W D, Hong S, Boesteanu A, Joyce S, Van Kaer L, ;1997;Immunity;6;469-77; 9133426