IMPC phenotypes (gene matching)
NOD.129S6-Cd1d1tm1Luc/Orl
| Status | Available to order |
| EMMA ID | EM:01803 |
| Citation information | RRID:IMSR_EM:01803 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | NOD.129S6-Cd1d1tm1Luc/Orl |
| Alternative name | NOD CD1d KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cd1d1tm1Luc |
| Gene/Transgene symbol | Cd1d1 |
Information from provider
| Provider | Thieblemont Nathalie |
| Provider affiliation | CNRS UMR 8147 |
| Genetic information | A 200 bp sequence in the third exon of the Cd1d1 gene was replaced by a neomycin resistance cassette. |
| Phenotypic information | Absence of natural killer T cells. |
| References |
|
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
- autoimmune response / MGI
- decreased regulatory T cell number / MGI
- kidney inflammation / MGI
- glomerulonephritis / MGI
- increased urine protein level / MGI
- renal interstitial fibrosis / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- glomerulosclerosis / MGI
- increased blood urea nitrogen level / MGI
- increased IgG3 level / MGI
- decreased interleukin-4 secretion / MGI
- renal tubule atrophy / MGI
- glomerular crescent / MGI
- abnormal liver morphology / MGI
- arrested T cell differentiation / MGI
- decreased acute inflammation / MGI
- decreased NK T cell number / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-gamma secretion / MGI
- decreased physiological sensitivity to xenobiotic / MGI
MGI phenotypes (gene matching)
- abnormal liver morphology / MGI
- decreased IgG level / MGI
- arrested T cell differentiation / MGI
- abnormal T cell activation / MGI
- abnormal antigen presentation / MGI
- autoimmune response / MGI
- kidney inflammation / MGI
- lung inflammation / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal dendritic cell antigen presentation / MGI
- glomerulonephritis / MGI
- increased urine protein level / MGI
- increased susceptibility to ischemic brain injury / MGI
- renal interstitial fibrosis / MGI
- decreased susceptibility to induced arthritis / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- decreased regulatory T cell number / MGI
- decreased acute inflammation / MGI
- glomerulosclerosis / MGI
- increased blood urea nitrogen level / MGI
- abnormal NK T cell morphology / MGI
- decreased NK T cell number / MGI
- abnormal NK T cell physiology / MGI
- abnormal CD4-positive T cell differentiation / MGI
- increased IgG3 level / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-gamma secretion / MGI
- decreased interleukin-2 secretion / MGI
- abnormal interleukin-4 secretion / MGI
- decreased interleukin-4 secretion / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- renal tubule atrophy / MGI
- glomerular crescent / MGI
Literature references
- CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4.;Mendiratta S K, Martin W D, Hong S, Boesteanu A, Joyce S, Van Kaer L, ;1997;Immunity;6;469-77; 9133426