NMRI-Tg(WAP-TAg)12Gmn/Kctt

Status	Available to order
EMMA ID	EM:01786
International strain name	NMRI-Tg(WAP-TAg)12Gmn/Kctt
Alternative name	WAP-SVT
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Wap-TAg)12Gmn
Gene/Transgene symbol	Tg(Wap-TAg)12Gmn

Information from provider

Provider	Adolf Graessmann
Provider affiliation	Institut für Molekularbiologie und Biochemie
Genetic information	Large T-antigen (outside of the early SV40 coding region) under transcription control of WAP (whey acidic protein) promoter.
Phenotypic information	Breast cancer formation.
Breeding history	Animals were generated in 1998 and continuously propagated. The transgene is kept at heterozygous state.
References	The SV40 small t-antigen prevents mammary gland differentiation and induces breast cancer formation in transgenic mice; truncated large T-antigen molecules harboring the intact p53 and pRb binding region do not have this effect.;Goetz F, Tzeng Y J, Guhl E, Merker J, Graessmann M, Graessmann A, ;2001;Oncogene;20;2325-32; 11402328

Information from EMMA

Archiving centre	Karolinska Institutet, Stockholm, Sweden

Literature references

The SV40 small t-antigen prevents mammary gland differentiation and induces breast cancer formation in transgenic mice; truncated large T-antigen molecules harboring the intact p53 and pRb binding region do not have this effect.;Goetz F, Tzeng Y J, Guhl E, Merker J, Graessmann M, Graessmann A, ;2001;Oncogene;20;2325-32; 11402328

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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