STOCK B2mtm1Unc H2-Ab1b-tm1Doi Tg(HLA-A/H2-D/B2M)1Bpe Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma/Orl

Status

Available to order

EMMA IDEM:01783
International strain nameSTOCK B2mtm1Unc H2-Ab1b-tm1Doi Tg(HLA-A/H2-D/B2M)1Bpe Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma/Orl
Alternative nameSure/L1, HLA-A2+HLA-DR1+/IAbeta2m
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolB2mtm1Unc, Tg(HLA-A/H2-D/B2M)1Bpe, Tg(HLA-DRA*0101, HLA-DRB1*0101)1Dma
Gene/Transgene symbolB2m, Tg(HLA-A/H2-D/B2M)1Bpe, Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma, H2-Ab1

Information from provider

ProviderYu Chun LONE
Provider affiliationCNRS 3 rue Michel Ange 75794 Paris Cedex 16
Genetic informationCommon name: Sure/L1. This strain is transgenic for HLA-A2/Beta2m and HLA-DR1 (Alpha and Beta chains) genes. Mutant mice also carry a null mutation in the beta-2 microglobulin gene (B2m) by homologous recombination (insertion of neomycin-resistance gene). The B2M protein is associated with major histocompatibility complex class I molecules. Furthermore these mice are deficient in the gene of major histocompatibility complex class II antigen, by mutation of the H2-Ab1 gene by homologous recombination.
Phenotypic informationMutant phenotype: HLA-A2+; HLA-DR1+; IaBeta-; Beta2m-; the fertility is good (4 to 6 pups) and these mice are not immunodeficient.
References
  • A mouse model of human adaptive immune functions: HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class II-knockout mice.;Pajot Anthony, Michel Marie-Louise, Fazilleau Nicolas, Pancré Véronique, Auriault Claude, Ojcius David M, Lemonnier François A, Lone Yu-Chun, ;2004;European journal of immunology;34;3060-9; 15468058

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous C57BL/6, homozygous C57BL/6
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • preweaning lethality, incomplete penetrance / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • small superior vagus ganglion / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
  • abnormal skin morphology / IMPC
  • hydrometra / IMPC
  • increased circulating phosphate level / IMPC
MGI phenotypes (allele matching)
  • decreased level of surface class I molecules / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased IgG level / MGI
  • abnormal pancreas morphology / MGI
  • decreased susceptibility to bacterial infection / MGI
  • increased IgM level / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased circulating serum albumin level / MGI
  • increased T-helper 1 cell number / MGI
  • abnormal interleukin level / MGI
  • abnormal tumor necrosis factor level / MGI
  • increased susceptibility to infection induced morbidity/mortality / MGI
  • absent CD8-positive, alpha-beta T cells / MGI
  • abnormal pancreatic beta cell morphology / MGI
  • abnormal T cell number / MGI
  • insulitis / MGI
MGI phenotypes (gene matching)
  • absent CD8-positive, alpha-beta T cells / MGI
  • decreased IgG level / MGI
  • decreased level of surface class I molecules / MGI
  • abnormal pancreas morphology / MGI
  • decreased susceptibility to bacterial infection / MGI
  • abnormal CD8-positive, alpha-beta cytotoxic T cell morphology / MGI
  • increased IgM level / MGI
  • insulitis / MGI
  • abnormal lateral geniculate nucleus morphology / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased susceptibility to parasitic infection / MGI
  • abnormal cytotoxic T cell physiology / MGI
  • abnormal pancreatic beta cell morphology / MGI
  • decreased circulating serum albumin level / MGI
  • hemochromatosis / MGI
  • abnormal T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • increased T-helper 1 cell number / MGI
  • increased gamma-delta T cell number / MGI
  • increased gamma-delta intraepithelial T cell number / MGI
  • increased tumor necrosis factor secretion / MGI
  • increased interleukin-3 secretion / MGI
  • decreased interleukin-4 secretion / MGI
  • abnormal interleukin level / MGI
  • abnormal tumor necrosis factor level / MGI
  • increased susceptibility to infection induced morbidity/mortality / MGI
  • abnormal immune system morphology / MGI
  • abnormal spleen morphology / MGI
  • abnormal immune system cell morphology / MGI
  • hemolytic anemia / MGI
  • postnatal growth retardation / MGI
  • abnormal immune system physiology / MGI
  • abnormal humoral immune response / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • autoimmune response / MGI
  • reduced fertility / MGI
  • premature death / MGI
  • abnormal T cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal spleen periarteriolar lymphoid sheath morphology / MGI
  • abnormal spleen marginal zone morphology / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal T cell physiology / MGI
  • abnormal dendritic cell antigen presentation / MGI
  • abnormal B cell physiology / MGI
  • abnormal immunoglobulin level / MGI
  • increased IgM level / MGI
  • abnormal immune system organ morphology / MGI
  • increased urine protein level / MGI
  • abnormal cytokine secretion / MGI
  • abnormal artery development / MGI
  • abnormal response/metabolism to endogenous compounds / MGI
  • absent CD4-positive, alpha beta T cells / MGI
  • abnormal lymphocyte physiology / MGI
  • insulitis / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased anti-single stranded DNA antibody level / MGI
  • increased anti-erythrocyte antigen antibody level / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • decreased susceptibility to experimental autoimmune myasthenia gravis / MGI
  • decreased regulatory T cell number / MGI
  • increased B cell number / MGI
  • decreased susceptibility to parasitic infection / MGI
  • increased susceptibility to parasitic infection / MGI
  • abnormal level of surface class II molecules / MGI
  • increased double-negative T cell number / MGI
  • decreased susceptibility to autoimmune disorder / MGI
  • cardiovascular system phenotype / MGI
  • immune system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • abnormal response to transplant / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased single-positive T cell number / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • absent spleen germinal center / MGI
  • decreased IgG1 level / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interleukin-12 secretion / MGI
  • abnormal lymph node cell ratio / MGI
  • abnormal neuron proliferation / MGI

Literature references

  • A mouse model of human adaptive immune functions: HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class II-knockout mice.;Pajot Anthony, Michel Marie-Louise, Fazilleau Nicolas, Pancré Véronique, Auriault Claude, Ojcius David M, Lemonnier François A, Lone Yu-Chun, ;2004;European journal of immunology;34;3060-9; 15468058
  • Dendritic cell-mediated, DNA-based vaccination against hepatitis C induces the multi-epitope-specific response of humanized, HLA transgenic mice.;Mishra Sasmita, Lavelle Bianca J, Desrosiers Joe, Ardito Matt T, Terry Frances, Martin William D, De Groot Anne S, Gregory Stephen H, ;2014;PloS one;9;e104606; 25111185

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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