STOCK B2mtm1Unc H2-Ab1b-tm1Doi Tg(HLA-A/H2-D/B2M)1Bpe Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma/Orl

Status

Available to order

EMMA IDEM:01783
Citation informationRRID:IMSR_EM:01783 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK B2mtm1Unc H2-Ab1b-tm1Doi Tg(HLA-A/H2-D/B2M)1Bpe Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma/Orl
Alternative nameSure/L1, HLA-A2+HLA-DR1+/IAbeta2m
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolB2mtm1Unc, Tg(HLA-A/H2-D/B2M)1Bpe, Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma, H2-Ab1b-tm1Doi
Gene/Transgene symbolB2m, Tg(HLA-A/H2-D/B2M)1Bpe, Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma, H2-Ab1

Information from provider

ProviderYu Chun LONE
Provider affiliationCNRS 3 rue Michel Ange 75794 Paris Cedex 16
Genetic informationCommon name: Sure/L1. This strain is transgenic for HLA-A2/Beta2m and HLA-DR1 (Alpha and Beta chains) genes. Mutant mice also carry a null mutation in the beta-2 microglobulin (B2m) gene by homologous recombination (insertion of neomycin-resistance gene). The B2M protein is associated with major histocompatibility complex class I molecules. Furthermore these mice are deficient in the H2-Ab1 (IAbeta) gene of major histocompatibility complex class II antigen, by homologous recombination mutation.
Phenotypic informationMutant phenotype: HLA-A2+; HLA-DR1+; IABeta-; Beta2m-; the fertility is good (4 to 6 pups) and these mice are not immunodeficient.
References
  • A mouse model of human adaptive immune functions: HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class II-knockout mice.;Pajot Anthony, Michel Marie-Louise, Fazilleau Nicolas, Pancré Véronique, Auriault Claude, Ojcius David M, Lemonnier François A, Lone Yu-Chun, ;2004;European journal of immunology;34;3060-9; 15468058

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous C57BL/6 males, homozygous C57BL/6 females
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • preweaning lethality, incomplete penetrance / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • small superior vagus ganglion / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
  • abnormal skin morphology / IMPC
  • hydrometra / IMPC
  • increased circulating phosphate level / IMPC
MGI phenotypes (allele matching)
  • decreased level of surface class I molecules / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased IgG level / MGI
  • abnormal pancreas morphology / MGI
  • decreased susceptibility to bacterial infection / MGI
  • increased IgM level / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased circulating serum albumin level / MGI
  • increased T-helper 1 cell number / MGI
  • abnormal interleukin level / MGI
  • abnormal tumor necrosis factor level / MGI
  • increased susceptibility to infection induced morbidity/mortality / MGI
  • absent CD8-positive, alpha-beta T cells / MGI
  • abnormal pancreatic beta cell morphology / MGI
  • abnormal T cell number / MGI
  • insulitis / MGI
MGI phenotypes (gene matching)
  • absent CD8-positive, alpha-beta T cells / MGI
  • decreased IgG level / MGI
  • decreased level of surface class I molecules / MGI
  • abnormal pancreas morphology / MGI
  • decreased susceptibility to bacterial infection / MGI
  • abnormal CD8-positive, alpha-beta cytotoxic T cell morphology / MGI
  • increased IgM level / MGI
  • insulitis / MGI
  • abnormal lateral geniculate nucleus morphology / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased susceptibility to parasitic infection / MGI
  • abnormal cytotoxic T cell physiology / MGI
  • abnormal pancreatic beta cell morphology / MGI
  • decreased circulating serum albumin level / MGI
  • hemochromatosis / MGI
  • abnormal T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • increased T-helper 1 cell number / MGI
  • increased gamma-delta T cell number / MGI
  • increased gamma-delta intraepithelial T cell number / MGI
  • increased tumor necrosis factor secretion / MGI
  • increased interleukin-3 secretion / MGI
  • decreased interleukin-4 secretion / MGI
  • abnormal interleukin level / MGI
  • abnormal tumor necrosis factor level / MGI
  • increased susceptibility to infection induced morbidity/mortality / MGI
  • abnormal immune system morphology / MGI
  • abnormal spleen morphology / MGI
  • abnormal immune system cell morphology / MGI
  • hemolytic anemia / MGI
  • postnatal growth retardation / MGI
  • abnormal immune system physiology / MGI
  • abnormal humoral immune response / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • autoimmune response / MGI
  • reduced fertility / MGI
  • premature death / MGI
  • abnormal T cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal spleen periarteriolar lymphoid sheath morphology / MGI
  • abnormal spleen marginal zone morphology / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal T cell physiology / MGI
  • abnormal dendritic cell antigen presentation / MGI
  • abnormal B cell physiology / MGI
  • abnormal immunoglobulin level / MGI
  • increased IgM level / MGI
  • abnormal immune system organ morphology / MGI
  • increased urine protein level / MGI
  • abnormal cytokine secretion / MGI
  • abnormal artery development / MGI
  • abnormal response/metabolism to endogenous compounds / MGI
  • absent CD4-positive, alpha beta T cells / MGI
  • abnormal lymphocyte physiology / MGI
  • insulitis / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased anti-single stranded DNA antibody level / MGI
  • increased anti-erythrocyte antigen antibody level / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • decreased susceptibility to experimental autoimmune myasthenia gravis / MGI
  • decreased regulatory T cell number / MGI
  • increased B cell number / MGI
  • decreased susceptibility to parasitic infection / MGI
  • increased susceptibility to parasitic infection / MGI
  • abnormal level of surface class II molecules / MGI
  • increased double-negative T cell number / MGI
  • decreased susceptibility to autoimmune disorder / MGI
  • cardiovascular system phenotype / MGI
  • immune system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • abnormal response to transplant / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased single-positive T cell number / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • absent spleen germinal center / MGI
  • decreased IgG1 level / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interleukin-12 secretion / MGI
  • abnormal lymph node cell ratio / MGI
  • abnormal neuron proliferation / MGI

Literature references

  • A mouse model of human adaptive immune functions: HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class II-knockout mice.;Pajot Anthony, Michel Marie-Louise, Fazilleau Nicolas, Pancré Véronique, Auriault Claude, Ojcius David M, Lemonnier François A, Lone Yu-Chun, ;2004;European journal of immunology;34;3060-9; 15468058
  • Dendritic cell-mediated, DNA-based vaccination against hepatitis C induces the multi-epitope-specific response of humanized, HLA transgenic mice.;Mishra Sasmita, Lavelle Bianca J, Desrosiers Joe, Ardito Matt T, Terry Frances, Martin William D, De Groot Anne S, Gregory Stephen H, ;2014;PloS one;9;e104606; 25111185

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).