IMPC phenotypes (gene matching)
C.129P2-Fcgr3tm1Jsv Fcgr1tm1Jsv/Cnrm
| Status | Available to order |
| EMMA ID | EM:01746 |
| Citation information | RRID:IMSR_EM:01746 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C.129P2-Fcgr3tm1Jsv Fcgr1tm1Jsv/Cnrm |
| Alternative name | CD64 CD16 (Balb/C) 566 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Fcgr1tm1Jsv, Fcgr3tm1Jsv |
| Gene/Transgene symbol | Fcgr1, Fcgr3 |
Information from provider
| Provider | Verbeek J.S. Verbeek J.S. |
| Provider affiliation | Leiden University Medical Center |
| Genetic information | Fcgr3: deletion of exon 3 (ligand binding EC2 domain) and 5' part of exon 4 (transmembrane domain), replaced by a PGK-hygromycin resistance cassette. Fcgr1: deletion of 3'-part of promoter, exon 1 (L1 domain), exon 2 (L2 domain) and 5'-part of exon 3 (ligand binding EC1 domain), replaced by a PGK-hygromycin resistance cassette. |
| Phenotypic information | Impaired IgG1, IgG2a and IgG2b antibody effector pathways. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- impaired macrophage phagocytosis / MGI
- decreased inflammatory response / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal cell-mediated immunity / MGI
- abnormal macrophage physiology / MGI
- abnormal macrophage antigen presentation / MGI
- abnormal dendritic cell antigen presentation / MGI
- increased IgG level / MGI
- abnormal type I hypersensitivity reaction / MGI
- decreased susceptibility to induced arthritis / MGI
- decreased susceptibility to autoimmune hemolytic anemia / MGI
- abnormal dendritic cell differentiation / MGI
- abnormal leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- impaired macrophage phagocytosis / MGI
- abnormal dendritic cell antigen presentation / MGI
- abnormal neutrophil physiology / MGI
- abnormal type I hypersensitivity reaction / MGI
- decreased susceptibility to induced arthritis / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased susceptibility to autoimmune hemolytic anemia / MGI
- impaired natural killer cell mediated cytotoxicity / MGI
- decreased susceptibility to type I hypersensitivity reaction / MGI
- decreased susceptibility to type II hypersensitivity reaction / MGI
- impaired neutrophil recruitment / MGI
- decreased mast cell degranulation / MGI
Literature references
- FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection.;Ioan-Facsinay A, de Kimpe S J, Hellwig S M M, van Lent P L, Hofhuis F M A, van Ojik H H, Sedlik C, da Silveira S A, Gerber J, de Jong Y F, Roozendaal R, Aarden L A, van den Berg W B, Saito T, Mosser D, Amigorena S, Izui S, van Ommen G J B, van Vugt M, van de Winkel J G J, Verbeek J S, ;2002;Immunity;16;391-402; 11911824