C.129P2-Fcgr3tm1Jsv Fcgr1tm1Jsv/Cnrm
Status | Available to order |
EMMA ID | EM:01746 |
International strain name | C.129P2-Fcgr3tm1Jsv Fcgr1tm1Jsv/Cnrm |
Alternative name | CD64 CD16 (Balb/C) 566 |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Fcgr1tm1Jsv, Fcgr3tm1Jsv |
Gene/Transgene symbol | Fcgr1, Fcgr3 |
Information from provider
Provider | Verbeek J.S. Verbeek J.S. |
Provider affiliation | Leiden University Medical Center |
Genetic information | Fcgr3: deletion of exon 3 (ligand binding EC2 domain) and 5' part of exon 4 (transmembrane domain), replaced by a PGK-hygromycin resistance cassette. Fcgr1: deletion of 3'-part of promoter, exon 1 (L1 domain), exon 2 (L2 domain) and 5'-part of exon 3 (ligand binding EC1 domain), replaced by a PGK-hygromycin resistance cassette. |
Phenotypic information | Impaired IgG1, IgG2a and IgG2b antibody effector pathways. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- impaired macrophage phagocytosis / MGI
- decreased inflammatory response / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal cell-mediated immunity / MGI
- abnormal macrophage physiology / MGI
- abnormal macrophage antigen presentation / MGI
- abnormal dendritic cell antigen presentation / MGI
- increased IgG level / MGI
- abnormal type I hypersensitivity reaction / MGI
- decreased susceptibility to induced arthritis / MGI
- decreased susceptibility to autoimmune hemolytic anemia / MGI
- abnormal dendritic cell differentiation / MGI
- abnormal leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- impaired macrophage phagocytosis / MGI
- abnormal dendritic cell antigen presentation / MGI
- abnormal neutrophil physiology / MGI
- abnormal type I hypersensitivity reaction / MGI
- decreased susceptibility to induced arthritis / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased susceptibility to autoimmune hemolytic anemia / MGI
- impaired natural killer cell mediated cytotoxicity / MGI
- decreased susceptibility to type I hypersensitivity reaction / MGI
- decreased susceptibility to type II hypersensitivity reaction / MGI
- impaired neutrophil recruitment / MGI
- decreased mast cell degranulation / MGI
Literature references
- FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection.;Ioan-Facsinay A, de Kimpe S J, Hellwig S M M, van Lent P L, Hofhuis F M A, van Ojik H H, Sedlik C, da Silveira S A, Gerber J, de Jong Y F, Roozendaal R, Aarden L A, van den Berg W B, Saito T, Mosser D, Amigorena S, Izui S, van Ommen G J B, van Vugt M, van de Winkel J G J, Verbeek J S, ;2002;Immunity;16;391-402; 11911824
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