C.129P2-Fcgr3tm1Jsv/Cnrm
Status | Available to order |
EMMA ID | EM:01745 |
International strain name | C.129P2-Fcgr3tm1Jsv/Cnrm |
Alternative name | CD16 (Balb/C) 193 |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Fcgr3tm1Jsv |
Gene/Transgene symbol | Fcgr3 |
Information from provider
Provider | Verbeek J.S. Verbeek J.S. |
Provider affiliation | Leiden University Medical Center |
Genetic information | Deletion of exon 3 (ligand binding EC2 domain) and 5'-part of exon 4 (transmembrane domain), replaced by a PGK-hygromycin resistance cassette. |
Phenotypic information | Impaired IgG1 and IgG2b antibody effector pathways. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- impaired macrophage phagocytosis / MGI
- abnormal dendritic cell antigen presentation / MGI
- abnormal neutrophil physiology / MGI
- abnormal type I hypersensitivity reaction / MGI
- decreased susceptibility to induced arthritis / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased susceptibility to autoimmune hemolytic anemia / MGI
- impaired natural killer cell mediated cytotoxicity / MGI
- decreased susceptibility to type I hypersensitivity reaction / MGI
- decreased susceptibility to type II hypersensitivity reaction / MGI
- impaired neutrophil recruitment / MGI
- decreased mast cell degranulation / MGI
Literature references
- Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice.;Hazenbos W L, Gessner J E, Hofhuis F M, Kuipers H, Meyer D, Heijnen I A, Schmidt R E, Sandor M, Capel P J, Daëron M, van de Winkel J G, Verbeek J S, ;1996;Immunity;5;181-8; 8769481
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