C.129P2-Fcgr3tm1Jsv/Cnrm

Status

Available to order

EMMA IDEM:01745
International strain nameC.129P2-Fcgr3tm1Jsv/Cnrm
Alternative nameCD16 (Balb/C) 193
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolFcgr3tm1Jsv
Gene/Transgene symbolFcgr3

Information from provider

ProviderVerbeek J.S. Verbeek J.S.
Provider affiliationLeiden University Medical Center
Genetic informationDeletion of exon 3 (ligand binding EC2 domain) and 5'-part of exon 4 (transmembrane domain), replaced by a PGK-hygromycin resistance cassette.
Phenotypic informationImpaired IgG1 and IgG2b antibody effector pathways.
References
  • Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice.;Hazenbos W L, Gessner J E, Hofhuis F M, Kuipers H, Meyer D, Heijnen I A, Schmidt R E, Sandor M, Capel P J, Daëron M, van de Winkel J G, Verbeek J S, ;1996;Immunity;5;181-8; 8769481

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal gait / IMPC
  • prolonged QT interval / IMPC
  • decreased circulating creatine kinase level / IMPC
  • increased heart rate / IMPC
  • increased anxiety-related response / IMPC
  • tremors / IMPC
MGI phenotypes (gene matching)
  • abnormal leukocyte cell number / MGI
  • increased neutrophil cell number / MGI
  • impaired macrophage phagocytosis / MGI
  • abnormal dendritic cell antigen presentation / MGI
  • abnormal neutrophil physiology / MGI
  • abnormal type I hypersensitivity reaction / MGI
  • decreased susceptibility to induced arthritis / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • decreased susceptibility to autoimmune hemolytic anemia / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • decreased susceptibility to type I hypersensitivity reaction / MGI
  • decreased susceptibility to type II hypersensitivity reaction / MGI
  • impaired neutrophil recruitment / MGI
  • decreased mast cell degranulation / MGI

Literature references

  • Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice.;Hazenbos W L, Gessner J E, Hofhuis F M, Kuipers H, Meyer D, Heijnen I A, Schmidt R E, Sandor M, Capel P J, Daëron M, van de Winkel J G, Verbeek J S, ;1996;Immunity;5;181-8; 8769481

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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