C.129P2-Fcgr3^tm1Jsv/Cnrm

Status	Available to order
EMMA ID	EM:01745
Citation information	RRID:IMSR_EM:01745 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C.129P2-Fcgr3^tm1Jsv/Cnrm
Alternative name	CD16 (Balb/C) 193
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Fcgr3^tm1Jsv
Gene/Transgene symbol	Fcgr3

Information from provider

Provider	Verbeek J.S. Verbeek J.S.
Provider affiliation	Leiden University Medical Center
Genetic information	Deletion of exon 3 (ligand binding EC2 domain) and 5'-part of exon 4 (transmembrane domain), replaced by a PGK-hygromycin resistance cassette.
Phenotypic information	Impaired IgG1 and IgG2b antibody effector pathways.
References	Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice.;Hazenbos W L, Gessner J E, Hofhuis F M, Kuipers H, Meyer D, Heijnen I A, Schmidt R E, Sandor M, Capel P J, Daëron M, van de Winkel J G, Verbeek J S, ;1996;Immunity;5;181-8; 8769481

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

IMPC phenotypes (gene matching)

abnormal gait / IMPC
prolonged QT interval / IMPC
decreased circulating creatine kinase level / IMPC
increased heart rate / IMPC
increased anxiety-related response / IMPC
tremors / IMPC

MGI phenotypes (gene matching)

abnormal leukocyte cell number / MGI
increased neutrophil cell number / MGI
impaired macrophage phagocytosis / MGI
abnormal dendritic cell antigen presentation / MGI
abnormal neutrophil physiology / MGI
abnormal type I hypersensitivity reaction / MGI
decreased susceptibility to induced arthritis / MGI
decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
decreased susceptibility to autoimmune hemolytic anemia / MGI
impaired natural killer cell mediated cytotoxicity / MGI
decreased susceptibility to type I hypersensitivity reaction / MGI
decreased susceptibility to type II hypersensitivity reaction / MGI
impaired neutrophil recruitment / MGI
decreased mast cell degranulation / MGI

Literature references

Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice.;Hazenbos W L, Gessner J E, Hofhuis F M, Kuipers H, Meyer D, Heijnen I A, Schmidt R E, Sandor M, Capel P J, Daëron M, van de Winkel J G, Verbeek J S, ;1996;Immunity;5;181-8; 8769481

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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C.129P2-Fcgr3tm1Jsv/Cnrm