B6;FVB-Tg(Slc6a3-icre)1Fto/Orl
| Status | Available to order |
| EMMA ID | EM:01738 |
| Citation information | RRID:IMSR_EM:01738 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;FVB-Tg(Slc6a3-icre)1Fto/Orl |
| Alternative name | C57BL/6.BAC-DATCre |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Slc6a3-icre)1Fto |
| Gene/Transgene symbol | Tg(Slc6a3-icre)1Fto |
Information from provider
| Provider | François Tronche |
| Provider affiliation | GEM 2358, CNRS (Centre National de la Recherche Scientifique) |
| Genetic information | The expression of cre recombinase (icre version) is targeted to dopaminergic neurons using a bacterial artificial chromosome (BAC) encompassing the dopamine transporter gene (Slc6a3 or Dat). The expression profile has been checked by immunofluorescence. The cre expression is restricted to DAT-positive neurons. The efficiency of recombination has been analysed for several loxP-containing targets (GRlox, Gt(ROSA)26Sor-lacZ reporter strain) in F. Tronche's laboratory (Paris). In adult animals, recombination can be observed in all dopaminergic neurons and appears to be restricted to these neurons. |
| Phenotypic information | No defects observed. |
| Breeding history | F0 FVB/N mice were backcrossed for four generations to C57BL/6. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Literature references
- Analysis of dopamine transporter gene expression pattern -- generation of DAT-iCre transgenic mice.;Turiault Marc, Parnaudeau Sébastien, Milet Aude, Parlato Rosanna, Rouzeau Jean-Denis, Lazar Monique, Tronche François, ;2007;The FEBS journal;274;3568-3577; 17565601