B10.Cg-H2k2 Tg(CD2-Ptpn11*C459S)1Axdr/AxdrH
| Status | Available to order |
| EMMA ID | EM:01734 |
| Citation information | RRID:IMSR_EM:01734 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B10.Cg-H2k2 Tg(CD2-Ptpn11*C459S)1Axdr/AxdrH |
| Alternative name | Shp2CS x B10.BR Line 1 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(CD2-Ptpn11*C459S)1Axdr |
| Gene/Transgene symbol | Tg(CD2-Ptpn11*C459S)1Axdr |
Information from provider
| Provider | Denis Alexander |
| Provider affiliation | The Babraham Institute, Babraham, Cambridge, CB2 4PB |
| Phenotypic information | Defective primary immune responses to T-dependent antigen and amplified cytokine secretion in response to antigenic challenge. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- The src homology 2 domain-containing tyrosine phosphatase 2 regulates primary T-dependent immune responses and Th cell differentiation.;Salmond Robert J, Huyer Gregory, Kotsoni Anastasia, Clements Lisa, Alexander Denis R, ;2005;Journal of immunology (Baltimore, Md. : 1950);175;6498-508; 16272304