FVB/N-Tg(Slc6a3-icre)1Fto/Orl

Status	Available to order
EMMA ID	EM:01710
International strain name	FVB/N-Tg(Slc6a3-icre)1Fto/Orl
Alternative name	FVB/N-BAC-DATCre
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Slc6a3-icre)1Fto
Gene/Transgene symbol	Tg(Slc6a3-icre)1Fto

Information from provider

Provider	François Tronche
Provider affiliation	GEM 2358, CNRS (Centre National de la Recherche Scientifique)
Genetic information	The expression of cre recombinase (icre version) is targeted to dopaminergic neurons using a bacterial artificial chromosome (BAC) encompassing the dopamine transporter (Slc6a3, or Dat) gene. The expression profile has been checked by immunofluorescence. The cre protein expression is restricted to DAT-positive neurons. The efficiency of recombination has been analysed for several loxP-containing targets (GR-lox, Gt(ROSA)26Sor-lacZ reporter strain) in F. Tronche's laboratory (Paris). In adult animals, a recombination can be observed in all dopaminergic neurons and appears to be restricted to this type of neurons.
Phenotypic information	No defects observed.
References	Analysis of dopamine transporter gene expression pattern -- generation of DAT-iCre transgenic mice.;Turiault Marc, Parnaudeau Sébastien, Milet Aude, Parlato Rosanna, Rouzeau Jean-Denis, Lazar Monique, Tronche François, ;2007;The FEBS journal;274;3568-3577; 17565601

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France

Literature references

Analysis of dopamine transporter gene expression pattern -- generation of DAT-iCre transgenic mice.;Turiault Marc, Parnaudeau Sébastien, Milet Aude, Parlato Rosanna, Rouzeau Jean-Denis, Lazar Monique, Tronche François, ;2007;The FEBS journal;274;3568-3577; 17565601

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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