B6.Cg-Tg(RP3-340H11)29Kel/H
| Status | Available to order |
| EMMA ID | EM:01709 |
| International strain name | B6.Cg-Tg(RP3-340H11)29Kel/H |
| Alternative name | Tg(RP21-340H11)29Kel |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(RP3-340H11)29Kel |
| Gene/Transgene symbol | Tg(RP3-340H11)29Kel |
Information from provider
| Provider | Gavin Kelsey |
| Provider affiliation | The Babraham Institute, Babraham, Cambridge, CB2 4PB |
| Genetic information | Mouse model of transient neonatal diabetes mellitus (TNDM). The transgene contains an unmodified human PAC (RP21-340H11), which comprises part of the TNDM locus (from chromosome 6q24). Imprinted inheritance associated with the disease. Created by pronuclear injection. |
| Phenotypic information | Neonatal hyperglycaemia (paternal transmission) in neonates and impaired glucose tolerance in adults. Transgenic mice show over-expression of the TNDM locus. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
Literature references
- Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM.;Ma Dan, Shield Julian P H, Dean Wendy, Leclerc Isabelle, Knauf Claude, Burcelin R R éMy, Rutter Guy A, Kelsey Gavin, ;2004;The Journal of clinical investigation;114;339-48; 15286800