B6.Cg-Tg(RP3-340H11)29Kel/H
| Status | Available to order |
| EMMA ID | EM:01709 |
| Citation information | RRID:IMSR_EM:01709 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(RP3-340H11)29Kel/H |
| Alternative name | Tg(RP21-340H11)29Kel |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(RP3-340H11)29Kel |
| Gene/Transgene symbol | Tg(RP3-340H11)29Kel |
Information from provider
| Provider | Gavin Kelsey |
| Provider affiliation | The Babraham Institute, Babraham, Cambridge, CB2 4PB |
| Genetic information | Mouse model of transient neonatal diabetes mellitus (TNDM). The transgene contains an unmodified human PAC (RP21-340H11), which comprises part of the TNDM locus (from chromosome 6q24). Imprinted inheritance associated with the disease. Created by pronuclear injection. |
| Phenotypic information | Neonatal hyperglycaemia (paternal transmission) in neonates and impaired glucose tolerance in adults. Transgenic mice show over-expression of the TNDM locus. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
Literature references
- Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM.;Ma Dan, Shield Julian P H, Dean Wendy, Leclerc Isabelle, Knauf Claude, Burcelin R R éMy, Rutter Guy A, Kelsey Gavin, ;2004;The Journal of clinical investigation;114;339-48; 15286800