IMPC phenotypes (gene matching)
- increased circulating HDL cholesterol level / IMPC
C3H.Cg-CrygsOpj/H
| Status | Available to order |
| EMMA ID | EM:01708 |
| International strain name | C3H.Cg-CrygsOpj/H |
| Alternative name | Crygs |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | CrygsOpj |
| Gene/Transgene symbol | Crygs |
Information from provider
| Provider | Mary Lyon |
| Provider affiliation | MRC Mammalian Genetics Unit |
| Genetic information | This stock has a single base-pair change in exon 2 of Crygs, crystallin gamma S gene (MGI allele ID:1861635), resulting in the formation of cataracts. The stock has been made homozygous for CrygsOpj and has also been cleared of the Pde6brd retinal degeneration allele. |
| Phenotypic information | Heterozygotes demonstrate opaque secondary fibre junctions. Homozygotes are at first like heterozygotes, but progress to total opacity by approximately 3 months of age. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Early-onset sutural cataract / Orphanet_98985
- Early-onset lamellar cataract / Orphanet_441452
Literature references
- A temperature-sensitive mutation of Crygs in the murine Opj cataract.;Sinha D, Wyatt M K, Sarra R, Jaworski C, Slingsby C, Thaung C, Pannell L, Robison W G, Favor J, Lyon M, Wistow G, ;2001;The Journal of biological chemistry;276;9308-15; 11121426