IMPC phenotypes (gene matching)
- increased circulating HDL cholesterol level / IMPC
C3H.Cg-CrygsOpj/H
| Status | Available to order |
| EMMA ID | EM:01708 |
| Citation information | RRID:IMSR_EM:01708 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3H.Cg-CrygsOpj/H |
| Alternative name | Crygs |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | CrygsOpj |
| Gene/Transgene symbol | Crygs |
Information from provider
| Provider | Mary Lyon |
| Provider affiliation | MRC Mammalian Genetics Unit |
| Genetic information | This stock has a single base-pair change in exon 2 of Crygs, crystallin gamma S gene (MGI allele ID:1861635), resulting in the formation of cataracts. The stock has been made homozygous for CrygsOpj and has also been cleared of the Pde6brd retinal degeneration allele. |
| Phenotypic information | Heterozygotes demonstrate opaque secondary fibre junctions. Homozygotes are at first like heterozygotes, but progress to total opacity by approximately 3 months of age. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Early-onset sutural cataract / Orphanet_98985
- Early-onset lamellar cataract / Orphanet_441452
Literature references
- A temperature-sensitive mutation of Crygs in the murine Opj cataract.;Sinha D, Wyatt M K, Sarra R, Jaworski C, Slingsby C, Thaung C, Pannell L, Robison W G, Favor J, Lyon M, Wistow G, ;2001;The Journal of biological chemistry;276;9308-15; 11121426