MGI phenotypes (allele matching)
STOCK Lim2To3/H
| Status | Available to order |
| EMMA ID | EM:01706 |
| Citation information | RRID:IMSR_EM:01706 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Lim2To3/H |
| Alternative name | To3 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Lim2To3 |
| Gene/Transgene symbol | Lim2 |
Information from provider
| Provider | Mary Lyon |
| Provider affiliation | MRC Mammalian Genetics Unit |
| Phenotypic information | Total lens opacity with microphthalmia in homozygotes. |
| References |
|
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Total early-onset cataract / Orphanet_98994
MGI phenotypes (gene matching)
- microphthalmia / MGI
- abnormal lens morphology / MGI
- cataract / MGI
- small lens / MGI
- disorganized secondary lens fibers / MGI
- abnormal eye size / MGI
- abnormal vitreous body morphology / MGI
- abnormal lens fiber morphology / MGI
- vision/eye phenotype / MGI
- ruptured lens capsule / MGI
- nuclear cataracts / MGI
- total cataracts / MGI
- vacuolated lens / MGI
Literature references
- Identification of a mutation in the MP19 gene, Lim2, in the cataractous mouse mutant To3.;Steele E C, Kerscher S, Lyon M F, Glenister P H, Favor J, Wang J, Church R L, ;1997;Molecular vision;3;5; 9238094
- Two new cataract loci, Ccw and To3, and further mapping of the Npp and Opj cataracts in the mouse.;Kerscher S, Glenister P H, Favor J, Lyon M F, ;1996;Genomics;36;17-21; 8812411
- A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea.;Favor J, ;1983;Mutation research;110;367-82; 6877261