BALB/cAnN-Rgs18m1H/H
Status | Available to order |
EMMA ID | EM:01701 |
International strain name | BALB/cAnN-Rgs18m1H/H |
Alternative name | BHV48 |
Strain type | Induced Mutant Strains : Chemically-induced |
Allele/Transgene symbol | Rgs18m1H |
Gene/Transgene symbol | Rgs18 |
Information from provider
Provider | David Keays |
Provider affiliation | MRC Harwell, Didcot, Oxon, OX11 0RD |
Genetic information | Stop mutation in exon 4 of the Rgs18 gene. |
Phenotypic information | Possible implications in regulating fear responses and possible role in anxiety disorders. |
Breeding history | Original background: BALB/cAnN; maintained background: BALB/cAnN; breeding history: maintained on BALB/cAnN. |
References |
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Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal megakaryocyte differentiation / MGI
- increased startle reflex / MGI
- abnormal bone marrow cell morphology/development / MGI
- no phenotypic analysis / MGI
- thrombocytopenia / MGI
- nervous system phenotype / MGI
- decreased thermal nociceptive threshold / MGI
- abnormal thrombosis / MGI
- behavior/neurological phenotype / MGI
- decreased bleeding time / MGI
- decreased megakaryocyte cell number / MGI
- increased platelet aggregation / MGI
- abnormal hemostasis / MGI
Literature references
- A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191
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