MGI phenotypes (allele matching)
BALB/cAnN-Rgs18m1H/H
| Status | Available to order |
| EMMA ID | EM:01701 |
| Citation information | RRID:IMSR_EM:01701 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | BALB/cAnN-Rgs18m1H/H |
| Alternative name | BHV48 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Rgs18m1H |
| Gene/Transgene symbol | Rgs18 |
Information from provider
| Provider | David Keays |
| Provider affiliation | MRC Harwell, Didcot, Oxon, OX11 0RD |
| Genetic information | Stop mutation in exon 4 of the Rgs18 gene. |
| Phenotypic information | Possible implications in regulating fear responses and possible role in anxiety disorders. |
| Breeding history | Original background: BALB/cAnN; maintained background: BALB/cAnN; breeding history: maintained on BALB/cAnN. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal megakaryocyte differentiation / MGI
- increased startle reflex / MGI
- abnormal bone marrow cell morphology/development / MGI
- no phenotypic analysis / MGI
- thrombocytopenia / MGI
- nervous system phenotype / MGI
- decreased thermal nociceptive threshold / MGI
- abnormal thrombosis / MGI
- behavior/neurological phenotype / MGI
- decreased bleeding time / MGI
- decreased megakaryocyte cell number / MGI
- increased platelet aggregation / MGI
- abnormal hemostasis / MGI
Literature references
- A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191