IMPC phenotypes (gene matching)
- decreased leukocyte cell number / IMPC
C3;C-EgfrWa5/H
| Status | Available to order |
| EMMA ID | EM:01696 |
| International strain name | C3;C-EgfrWa5/H |
| Alternative name | Egfr |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | EgfrWa5 |
| Gene/Transgene symbol | Egfr |
Information from provider
| Provider | Caroline Thaung |
| Provider affiliation | MRC Mammalian Genetics Unit |
| Phenotypic information | Heterozygotes are born with open eyelids (eyes otherwise normal), curly whiskers and wavy coats. |
| References |
|
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Neonatal inflammatory skin and bowel disease / Orphanet_294023
MGI phenotypes (allele matching)
- alopecia / MGI
- long snout / MGI
- mandible hypoplasia / MGI
- abnormal vagina orifice morphology / MGI
- decreased body weight / MGI
- loss of vibrissae / MGI
- postnatal growth retardation / MGI
- abnormal eye morphology / MGI
- abnormal fertility/fecundity / MGI
- asymmetric snout / MGI
- postnatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- narrow snout / MGI
- waved hair / MGI
- curly vibrissae / MGI
- eyelids open at birth / MGI
- corneal scarring / MGI
- abnormal hair texture / MGI
- abnormal vibrissa morphology / MGI
- abnormal placenta morphology / MGI
- abnormal placenta labyrinth morphology / MGI
- decreased spongiotrophoblast size / MGI
- preweaning lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
MGI phenotypes (gene matching)
- short mandible / MGI
- cleft palate / MGI
- decreased leukocyte cell number / MGI
- abnormal aorta morphology / MGI
- abnormal myocardial fiber morphology / MGI
- abnormal hair follicle morphology / MGI
- decreased hair follicle number / MGI
- abnormal hair follicle orientation / MGI
- distorted hair follicle pattern / MGI
- increased curvature of hairs / MGI
- increased curvature of guard hairs / MGI
- waved hair / MGI
- alopecia / MGI
- sparse hair / MGI
- short hair / MGI
- delayed hair appearance / MGI
- abnormal hair cycle / MGI
- long snout / MGI
- pointed snout / MGI
- mandible hypoplasia / MGI
- abnormal esophageal epithelium morphology / MGI
- abnormal intestine morphology / MGI
- abnormal colon morphology / MGI
- increased foot pad pigmentation / MGI
- abnormal nail morphology / MGI
- long toenails / MGI
- abnormal liver morphology / MGI
- abnormal hepatocyte morphology / MGI
- abnormal mammary gland morphology / MGI
- abnormal tongue morphology / MGI
- abnormal filiform papillae morphology / MGI
- abnormal tongue epithelium morphology / MGI
- decreased brain size / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal olfactory bulb morphology / MGI
- small cerebellum / MGI
- abnormal cerebellum external granule cell layer morphology / MGI
- decreased Purkinje cell number / MGI
- abnormal dorsal root ganglion morphology / MGI
- abnormal sensory neuron innervation pattern / MGI
- abnormal vagina orifice morphology / MGI
- abnormal lung development / MGI
- atelectasis / MGI
- thick pulmonary interalveolar septum / MGI
- flaky skin / MGI
- thick skin / MGI
- abnormal epidermal layer morphology / MGI
- thin epidermis / MGI
- thick epidermis / MGI
- abnormal epidermis stratum basale morphology / MGI
- abnormal epidermis stratum granulosum morphology / MGI
- abnormal epidermis stratum corneum morphology / MGI
- decreased body weight / MGI
- weight loss / MGI
- decreased body size / MGI
- curly vibrissae / MGI
- wavy vibrissae / MGI
- loss of vibrissae / MGI
- short vibrissae / MGI
- absent vibrissae / MGI
- microphthalmia / MGI
- eyelids open at birth / MGI
- cataract / MGI
- fused cornea and lens / MGI
- corneal opacity / MGI
- corneal scarring / MGI
- abnormal eyelid morphology / MGI
- absent eyelids / MGI
- dehydration / MGI
- abnormal coat appearance / MGI
- disheveled coat / MGI
- cyanosis / MGI
- cardiac hypertrophy / MGI
- abnormal intestinal absorption / MGI
- decreased embryo size / MGI
- abnormal placenta morphology / MGI
- decreased trophoblast giant cell number / MGI
- placental labyrinth hypoplasia / MGI
- abnormal placenta labyrinth morphology / MGI
- postnatal growth retardation / MGI
- abnormal lactation / MGI
- abnormal pancreas morphology / MGI
- respiratory failure / MGI
- respiratory distress / MGI
- abnormal hair growth / MGI
- abnormal hair texture / MGI
- premature death / MGI
- abnormal eye morphology / MGI
- abnormal skin pigmentation / MGI
- abnormal vibrissa morphology / MGI
- abnormal fertility/fecundity / MGI
- abnormal outer ear morphology / MGI
- abnormal bronchus morphology / MGI
- abnormal terminal bronchiole morphology / MGI
- abnormal pulmonary alveolus morphology / MGI
- abnormal type II pneumocyte morphology / MGI
- abnormal lung interstitium morphology / MGI
- heart left ventricle hypertrophy / MGI
- increased heart rate / MGI
- abnormal inner cell mass morphology / MGI
- abnormal semilunar valve morphology / MGI
- abnormal aortic valve morphology / MGI
- no phenotypic analysis / MGI
- cardiac fibrosis / MGI
- nervous system phenotype / MGI
- abnormal hair follicle development / MGI
- abnormal hair shaft morphology / MGI
- abnormal hair medulla / MGI
- increased left ventricle systolic pressure / MGI
- dry skin / MGI
- prolonged PR interval / MGI
- abnormal heart left ventricle morphology / MGI
- decreased fetal size / MGI
- small pancreas / MGI
- abnormal maternal decidual layer morphology / MGI
- small placenta / MGI
- dilated kidney collecting duct / MGI
- abnormal trophoblast layer morphology / MGI
- cachexia / MGI
- abnormal pancreatic beta cell morphology / MGI
- abnormal exocrine pancreas morphology / MGI
- growth/size/body region phenotype / MGI
- reproductive system phenotype / MGI
- decreased cornea thickness / MGI
- increased circulating creatinine level / MGI
- increased blood urea nitrogen level / MGI
- decreased ventricle muscle contractility / MGI
- dilated terminal bronchiole tubes / MGI
- impaired lung alveolus development / MGI
- aortic valve regurgitation / MGI
- calcified aortic valve / MGI
- aortic valve stenosis / MGI
- thin cerebral cortex / MGI
- abnormal fungiform papillae morphology / MGI
- increased pulse pressure / MGI
- petechiae / MGI
- hematoma / MGI
- asymmetric snout / MGI
- plush coat / MGI
- disorganized pancreatic islets / MGI
- failure of eyelid fusion / MGI
- decreased embryo weight / MGI
- abnormal eyelid development / MGI
- abnormal hair cortex keratinization / MGI
- abnormal skin appearance / MGI
- rough coat / MGI
- prolonged RR interval / MGI
- increased heart left ventricle size / MGI
- enlarged aortic valve / MGI
- thick aortic valve / MGI
- abnormal hair follicle inner root sheath morphology / MGI
- integument phenotype / MGI
- dilated respiratory conducting tubes / MGI
- decreased alveolar lamellar body number / MGI
- abnormal bronchiole epithelium morphology / MGI
- abnormal pulmonary alveolus epithelium morphology / MGI
- abnormal pulmonary interalveolar septum morphology / MGI
- abnormal pulmonary acinus morphology / MGI
- abnormal branching involved in lung morphogenesis / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality at implantation, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- preweaning lethality, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- embryonic lethality between implantation and somite formation, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- decreased fibroblast cell migration / MGI
- enhanced osteoblast differentiation / MGI
- abnormal heart valve physiology / MGI
- increased cardiac stroke volume / MGI
- decreased spongiotrophoblast size / MGI
- abnormal submandibular gland branching morphogenesis / MGI
- premature chondrocyte differentiation / MGI
- small Meckel's cartilage / MGI
- narrow snout / MGI
Literature references
- Novel ENU-induced eye mutations in the mouse: models for human eye disease.;Thaung Caroline, West Katrine, Clark Brian J, McKie Lisa, Morgan Joanne E, Arnold Karen, Nolan Patrick M, Peters Jo, Hunter A Jackie, Brown Steve D M, Jackson Ian J, Cross Sally H, ;2002;Human molecular genetics;11;755-67; 11929848