IMPC phenotypes (gene matching)
NOD.Cg-(D1Mit15-D1Mit359)C57BL/6J Cd1d1tm1Luc/Orl
| Status | Available to order |
| EMMA ID | EM:01648 |
| International strain name | NOD.Cg-(D1Mit15-D1Mit359)C57BL/6J Cd1d1tm1Luc/Orl |
| Alternative name | NOD.B6-L2.CD1d-/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cd1d1tm1Luc, Nktcn1C57BL/6J, Stia1C57BL/6J |
| Gene/Transgene symbol | Cd1d1, Nktcn1, Stia1 |
Information from provider
| Provider | André Herbelin |
| Provider affiliation | GEM 2358, CNRS (Centre National de la Recherche Scientifique) |
| Genetic information | NOD congenic strain with the distal chromosome 1 from C57BL/6 line 2 and Cd1d knock-out mutation. |
| Phenotypic information | This line bears the main QTL controlling serum levels of IgG1 and IG2b in NOD mice. The same interval also controls severity of experimental arthritis, number and function of invariant natural killer T (iNKT) cells, IgE serum levels and increase in resistance to endotoxinic shock. |
| Breeding history | 20 generations of backcross followed by sister-brother matings. Selection of subcongenics by additional backcrosses. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
- autoimmune response / MGI
- decreased regulatory T cell number / MGI
- kidney inflammation / MGI
- glomerulonephritis / MGI
- increased urine protein level / MGI
- renal interstitial fibrosis / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- glomerulosclerosis / MGI
- increased blood urea nitrogen level / MGI
- increased IgG3 level / MGI
- decreased interleukin-4 secretion / MGI
- renal tubule atrophy / MGI
- glomerular crescent / MGI
- abnormal liver morphology / MGI
- arrested T cell differentiation / MGI
- decreased acute inflammation / MGI
- decreased NK T cell number / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-gamma secretion / MGI
- decreased physiological sensitivity to xenobiotic / MGI
MGI phenotypes (gene matching)
- abnormal liver morphology / MGI
- decreased IgG level / MGI
- arrested T cell differentiation / MGI
- abnormal T cell activation / MGI
- abnormal antigen presentation / MGI
- autoimmune response / MGI
- kidney inflammation / MGI
- lung inflammation / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal dendritic cell antigen presentation / MGI
- glomerulonephritis / MGI
- increased urine protein level / MGI
- increased susceptibility to ischemic brain injury / MGI
- renal interstitial fibrosis / MGI
- decreased susceptibility to induced arthritis / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- decreased regulatory T cell number / MGI
- decreased acute inflammation / MGI
- glomerulosclerosis / MGI
- increased blood urea nitrogen level / MGI
- abnormal NK T cell morphology / MGI
- decreased NK T cell number / MGI
- abnormal NK T cell physiology / MGI
- abnormal CD4-positive T cell differentiation / MGI
- increased IgG3 level / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-gamma secretion / MGI
- decreased interleukin-2 secretion / MGI
- abnormal interleukin-4 secretion / MGI
- decreased interleukin-4 secretion / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- renal tubule atrophy / MGI
- glomerular crescent / MGI
Literature references
- Genetic influences on the end-stage effector phase of arthritis.;Ji H, Gauguier D, Ohmura K, Gonzalez A, Duchatelle V, Danoy P, Garchon H J, Degott C, Lathrop M, Benoist C, Mathis D, ;2001;The Journal of experimental medicine;194;321-30; 11489951
- Defective Fc gamma RII gene expression in macrophages of NOD mice: genetic linkage with up-regulation of IgG1 and IgG2b in serum.;Luan J J, Monteiro R C, Sautès C, Fluteau G, Eloy L, Fridman W H, Bach J F, Garchon H J, ;1996;Journal of immunology (Baltimore, Md. : 1950);157;4707-16; 8906852
- Genetic control of NKT cell numbers maps to major diabetes and lupus loci.;Esteban Luis M, Tsoutsman Tatiana, Jordan Margaret A, Roach Daniel, Poulton Lynn D, Brooks Andrew, Naidenko Olga V, Sidobre Stephane, Godfrey Dale I, Baxter Alan G, ;2003;Journal of immunology (Baltimore, Md. : 1950);171;2873-8; 12960309