FVB.129P2-Brca1tm1Brn/Cnrm

Status

Available to order

EMMA IDEM:01645
Citation informationRRID:IMSR_EM:01645 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameFVB.129P2-Brca1tm1Brn/Cnrm
Alternative nameBr1F
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolBrca1tm1Brn
Gene/Transgene symbolBrca1

Information from provider

ProviderAnton Berns
Provider affiliationResearch - Animal Facility, The Netherlands Cancer Institute
Genetic informationInsertion of 5' (intron 4) and 3' (intron 13) loxP sites in the Brca1 gene, by homologous recombination in ES cells.
Phenotypic informationNone.
Breeding history6 generations backcrossed on FVB/N.
References
  • Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes.;Clark-Knowles Katherine V, Garson Kenneth, Jonkers Jos, Vanderhyden Barbara C, ;2007;Experimental cell research;313;133-45; 17070800

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal heart development / MGI
  • abnormal cell death / MGI
  • decreased cell proliferation / MGI
  • abnormal hair follicle morphology / MGI
  • decreased hair follicle number / MGI
  • abnormal awl hair morphology / MGI
  • kinked tail / MGI
  • abnormal mammary gland morphology / MGI
  • abnormal mammary gland development / MGI
  • mammary gland hyperplasia / MGI
  • abnormal branching of the mammary ductal tree / MGI
  • abnormal embryonic neuroepithelial layer differentiation / MGI
  • exencephaly / MGI
  • open neural tube / MGI
  • abnormal ovary morphology / MGI
  • abnormal uterine cervix squamous epithelium morphology / MGI
  • small testis / MGI
  • arrest of spermatogenesis / MGI
  • dermatitis / MGI
  • increased body weight / MGI
  • decreased body weight / MGI
  • hyperactivity / MGI
  • increased mortality induced by gamma-irradiation / MGI
  • absent mesoderm / MGI
  • abnormal axial mesoderm / MGI
  • incomplete somite formation / MGI
  • failure of primitive streak formation / MGI
  • absent egg cylinders / MGI
  • decreased embryo size / MGI
  • absent amniotic folds / MGI
  • absent trophoblast giant cells / MGI
  • postnatal growth retardation / MGI
  • mammary gland duct hyperplasia / MGI
  • male infertility / MGI
  • neoplasm / MGI
  • increased cellular sensitivity to gamma-irradiation / MGI
  • increased tumor incidence / MGI
  • increased T cell derived lymphoma incidence / MGI
  • abnormal hair growth / MGI
  • abnormal coat/hair pigmentation / MGI
  • abnormal developmental patterning / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal extraembryonic tissue morphology / MGI
  • abnormal skin pigmentation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal primitive streak formation / MGI
  • disorganized extraembryonic tissue / MGI
  • uterus hyperplasia / MGI
  • spina bifida / MGI
  • abnormal cell cycle / MGI
  • abnormal egg cylinder morphology / MGI
  • abnormal cell migration / MGI
  • abnormal cell nucleus morphology / MGI
  • enlarged tail bud / MGI
  • abnormal cell adhesion / MGI
  • abnormal nervous system morphology / MGI
  • abnormal embryonic-extraembryonic boundary morphology / MGI
  • embryonic growth retardation / MGI
  • disorganized embryonic tissue / MGI
  • abnormal chromosome number / MGI
  • increased incidence of tumors by ionizing radiation induction / MGI
  • abnormal trophoblast layer morphology / MGI
  • azoospermia / MGI
  • cellular phenotype / MGI
  • reproductive system phenotype / MGI
  • increased apoptosis / MGI
  • early cellular replicative senescence / MGI
  • increased liver tumor incidence / MGI
  • abnormal small intestinal villus morphology / MGI
  • decreased survivor rate / MGI
  • decreased subcutaneous adipose tissue amount / MGI
  • endometrium hyperplasia / MGI
  • abnormal mammary gland duct morphology / MGI
  • abnormal mammary gland epithelium morphology / MGI
  • abnormal mammary gland lobule morphology / MGI
  • increased mammary gland ductal carcinoma incidence / MGI
  • empty decidua capsularis / MGI
  • abnormal mitotic spindle morphology / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • increased mammary gland epithelial cell proliferation / MGI
  • decreased mammary gland epithelial cell proliferation / MGI
  • increased hepatoma incidence / MGI
  • increased mammary gland tumor incidence / MGI
  • increased lipoma incidence / MGI
  • mortality/aging / MGI
  • abnormal double-strand DNA break repair / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality between implantation and placentation, complete penetrance / MGI
  • embryonic lethality between implantation and somite formation, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • abnormal visceral endoderm morphology / MGI
  • abnormal parietal endoderm morphology / MGI
  • decreased fibroblast proliferation / MGI
  • increased lymphoma incidence / MGI
  • decreased small intestinal villus height / MGI
  • increased mammary gland apoptosis / MGI

Literature references

  • Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes.;Clark-Knowles Katherine V, Garson Kenneth, Jonkers Jos, Vanderhyden Barbara C, ;2007;Experimental cell research;313;133-45; 17070800

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).