- abnormal heart development / MGI
- abnormal cell death / MGI
- decreased cell proliferation / MGI
- abnormal hair follicle morphology / MGI
- decreased hair follicle number / MGI
- abnormal awl hair morphology / MGI
- kinked tail / MGI
- abnormal mammary gland morphology / MGI
- abnormal mammary gland development / MGI
- mammary gland hyperplasia / MGI
- abnormal branching of the mammary ductal tree / MGI
- abnormal embryonic neuroepithelial layer differentiation / MGI
- exencephaly / MGI
- open neural tube / MGI
- abnormal ovary morphology / MGI
- abnormal uterine cervix squamous epithelium morphology / MGI
- small testis / MGI
- arrest of spermatogenesis / MGI
- dermatitis / MGI
- increased body weight / MGI
- decreased body weight / MGI
- hyperactivity / MGI
- increased mortality induced by gamma-irradiation / MGI
- absent mesoderm / MGI
- abnormal axial mesoderm / MGI
- incomplete somite formation / MGI
- failure of primitive streak formation / MGI
- absent egg cylinders / MGI
- decreased embryo size / MGI
- absent amniotic folds / MGI
- absent trophoblast giant cells / MGI
- postnatal growth retardation / MGI
- mammary gland duct hyperplasia / MGI
- male infertility / MGI
- neoplasm / MGI
- increased cellular sensitivity to gamma-irradiation / MGI
- increased tumor incidence / MGI
- increased T cell derived lymphoma incidence / MGI
- abnormal hair growth / MGI
- abnormal coat/hair pigmentation / MGI
- abnormal developmental patterning / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal extraembryonic tissue morphology / MGI
- abnormal skin pigmentation / MGI
- no abnormal phenotype detected / MGI
- abnormal primitive streak formation / MGI
- disorganized extraembryonic tissue / MGI
- uterus hyperplasia / MGI
- spina bifida / MGI
- abnormal cell cycle / MGI
- abnormal egg cylinder morphology / MGI
- abnormal cell migration / MGI
- abnormal cell nucleus morphology / MGI
- enlarged tail bud / MGI
- abnormal cell adhesion / MGI
- abnormal nervous system morphology / MGI
- abnormal embryonic-extraembryonic boundary morphology / MGI
- embryonic growth retardation / MGI
- disorganized embryonic tissue / MGI
- abnormal chromosome number / MGI
- increased incidence of tumors by ionizing radiation induction / MGI
- abnormal trophoblast layer morphology / MGI
- azoospermia / MGI
- cellular phenotype / MGI
- reproductive system phenotype / MGI
- increased apoptosis / MGI
- early cellular replicative senescence / MGI
- increased liver tumor incidence / MGI
- abnormal small intestinal villus morphology / MGI
- decreased survivor rate / MGI
- decreased subcutaneous adipose tissue amount / MGI
- endometrium hyperplasia / MGI
- abnormal mammary gland duct morphology / MGI
- abnormal mammary gland epithelium morphology / MGI
- abnormal mammary gland lobule morphology / MGI
- increased mammary gland ductal carcinoma incidence / MGI
- empty decidua capsularis / MGI
- abnormal mitotic spindle morphology / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- increased mammary gland epithelial cell proliferation / MGI
- decreased mammary gland epithelial cell proliferation / MGI
- increased hepatoma incidence / MGI
- increased mammary gland tumor incidence / MGI
- increased lipoma incidence / MGI
- mortality/aging / MGI
- abnormal double-strand DNA break repair / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality between implantation and placentation, complete penetrance / MGI
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- abnormal visceral endoderm morphology / MGI
- abnormal parietal endoderm morphology / MGI
- decreased fibroblast proliferation / MGI
- increased lymphoma incidence / MGI
- decreased small intestinal villus height / MGI
- increased mammary gland apoptosis / MGI
FVB.129P2-Brca1tm1Brn/Cnrm
Status | Available to order |
EMMA ID | EM:01645 |
International strain name | FVB.129P2-Brca1tm1Brn/Cnrm |
Alternative name | Br1F |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Brca1tm1Brn |
Gene/Transgene symbol | Brca1 |
Information from provider
Provider | Anton Berns |
Provider affiliation | Research - Animal Facility, The Netherlands Cancer Institute |
Genetic information | Insertion of 5' (intron 4) and 3' (intron 13) loxP sites in the Brca1 gene, by homologous recombination in ES cells. |
Phenotypic information | None. |
Breeding history | 6 generations backcrossed on FVB/N. |
References |
|
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Fanconi anemia / Orphanet_84
- Hereditary breast and ovarian cancer syndrome / Orphanet_145
- Cholangiocarcinoma / Orphanet_70567
MGI phenotypes (gene matching)
Literature references
- Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes.;Clark-Knowles Katherine V, Garson Kenneth, Jonkers Jos, Vanderhyden Barbara C, ;2007;Experimental cell research;313;133-45; 17070800
Information on how we integrate external resources can be found here
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