NOD.B6-Ptprcb/Orl

Status

Available to order

EMMA IDEM:01637
Citation informationRRID:IMSR_EM:01637 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameNOD.B6-Ptprcb/Orl
Alternative nameNOD.CD45.2
Strain typeSpontaneous
Allele/Transgene symbolPtprcb
Gene/Transgene symbolPtprc

Information from provider

ProviderFrancoise Lepault
Provider affiliationINSERM U561 - Hopital Saint Vincent de Paul
Genetic informationNOD congenic strain for Ptprcb (CD45.2) from C57BL/6.
Phenotypic informationNo phenotypic changes detected. Diabetes incidence similar to wild-type NOD mice.
Breeding historyNOD mice were crossed with C57BL/6 mice and backcrossed to the NOD background for more than 10 times, before brother-sister intercross. Mice are homozygous for Ptprcb (CD45.2). No breeding problem with this line.
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal long bone metaphysis morphology / MGI
  • abnormal leukocyte cell number / MGI
  • increased neutrophil cell number / MGI
  • decreased leukocyte cell number / MGI
  • extramedullary hematopoiesis / MGI
  • abnormal erythropoiesis / MGI
  • enlarged spleen / MGI
  • spleen hyperplasia / MGI
  • enlarged lymph nodes / MGI
  • decreased thymocyte number / MGI
  • abnormal immune system cell morphology / MGI
  • abnormal myelination / MGI
  • abnormal oligodendrocyte morphology / MGI
  • abnormal osteoclast physiology / MGI
  • abnormal digestion / MGI
  • abnormal immune system physiology / MGI
  • abnormal humoral immune response / MGI
  • thymus hypoplasia / MGI
  • arrested T cell differentiation / MGI
  • abnormal T cell activation / MGI
  • liver inflammation / MGI
  • lung inflammation / MGI
  • premature death / MGI
  • abnormal T cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal bone marrow cell morphology/development / MGI
  • abnormal lymphopoiesis / MGI
  • abnormal double-positive T cell morphology / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal T cell physiology / MGI
  • abnormal B cell number / MGI
  • increased IgA level / MGI
  • abnormal immune system organ morphology / MGI
  • glomerulonephritis / MGI
  • increased urine protein level / MGI
  • abnormal cytokine secretion / MGI
  • no phenotypic analysis / MGI
  • kidney failure / MGI
  • oliguria / MGI
  • abnormal thymocyte activation / MGI
  • abnormal T cell subpopulation ratio / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • abnormal T cell selection / MGI
  • abnormal positive T cell selection / MGI
  • increased B-1 B cell number / MGI
  • abnormal osteoclast morphology / MGI
  • increased B cell number / MGI
  • increased T cell number / MGI
  • decreased B cell number / MGI
  • decreased T cell number / MGI
  • abnormal response to infection / MGI
  • diarrhea / MGI
  • decreased cytotoxic T cell cytolysis / MGI
  • increased double-negative T cell number / MGI
  • decreased double-positive T cell number / MGI
  • decreased B cell proliferation / MGI
  • decreased T cell proliferation / MGI
  • increased susceptibility to autoimmune disorder / MGI
  • immune system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • decreased susceptibility to type I hypersensitivity reaction / MGI
  • CNS inflammation / MGI
  • increased T cell apoptosis / MGI
  • abnormal T cell morphology / MGI
  • increased NK cell number / MGI
  • abnormal memory T cell number / MGI
  • increased memory T cell number / MGI
  • decreased memory T cell number / MGI
  • absent T cells / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • abnormal CD4-positive T cell differentiation / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • abnormal CD8-positive, alpha-beta T cell differentiation / MGI
  • increased single-positive T cell number / MGI
  • decreased single-positive T cell number / MGI
  • increased plasma cell number / MGI
  • lymph node hyperplasia / MGI
  • abnormal granulocyte differentiation / MGI
  • increased dendritic cell number / MGI
  • decreased B-1a cell number / MGI
  • increased B-1b cell number / MGI
  • decreased B-1b cell number / MGI
  • decreased follicular B cell number / MGI
  • increased transitional stage B cell number / MGI
  • abnormal follicular B cell physiology / MGI
  • decreased B-2 B cell number / MGI
  • decreased mature B cell number / MGI
  • abnormal B cell activation / MGI
  • abnormal leukocyte morphology / MGI
  • decreased gamma-delta intraepithelial T cell number / MGI
  • abnormal CD4-positive, alpha-beta intraepithelial T cell morphology / MGI
  • increased spleen red pulp amount / MGI
  • increased spleen white pulp amount / MGI
  • increased IgG2a level / MGI
  • increased plasmacytoid dendritic cell number / MGI
  • abnormal chemokine secretion / MGI
  • decreased memory B cell number / MGI
  • decreased mast cell degranulation / MGI
  • abnormal intraepithelial T cell morphology / MGI
  • abnormal intraepithelial T cell number / MGI
  • decreased oligodendrocyte number / MGI
  • increased DN3 thymocyte number / MGI
  • decreased DN4 thymocyte number / MGI
  • abnormal NK cell physiology / MGI
  • mortality/aging / MGI
  • decreased CD4-positive, alpha-beta memory T cell number / MGI
  • decreased CD8-positive, alpha-beta memory T cell number / MGI
  • lethality at weaning, incomplete penetrance / MGI
  • increased alpha-beta T cell number / MGI
  • decreased CD8-positive, naive alpha-beta T cell number / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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