- abnormal long bone metaphysis morphology / MGI
- abnormal leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- decreased leukocyte cell number / MGI
- extramedullary hematopoiesis / MGI
- abnormal erythropoiesis / MGI
- enlarged spleen / MGI
- spleen hyperplasia / MGI
- enlarged lymph nodes / MGI
- decreased thymocyte number / MGI
- abnormal immune system cell morphology / MGI
- abnormal myelination / MGI
- abnormal oligodendrocyte morphology / MGI
- abnormal osteoclast physiology / MGI
- abnormal digestion / MGI
- abnormal immune system physiology / MGI
- abnormal humoral immune response / MGI
- thymus hypoplasia / MGI
- arrested T cell differentiation / MGI
- abnormal T cell activation / MGI
- liver inflammation / MGI
- lung inflammation / MGI
- premature death / MGI
- abnormal T cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal bone marrow cell morphology/development / MGI
- abnormal lymphopoiesis / MGI
- abnormal double-positive T cell morphology / MGI
- increased susceptibility to viral infection / MGI
- abnormal T cell physiology / MGI
- abnormal B cell number / MGI
- increased IgA level / MGI
- abnormal immune system organ morphology / MGI
- glomerulonephritis / MGI
- increased urine protein level / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- kidney failure / MGI
- oliguria / MGI
- abnormal thymocyte activation / MGI
- abnormal T cell subpopulation ratio / MGI
- increased anti-double stranded DNA antibody level / MGI
- abnormal T cell selection / MGI
- abnormal positive T cell selection / MGI
- increased B-1 B cell number / MGI
- abnormal osteoclast morphology / MGI
- increased B cell number / MGI
- increased T cell number / MGI
- decreased B cell number / MGI
- decreased T cell number / MGI
- abnormal response to infection / MGI
- diarrhea / MGI
- decreased cytotoxic T cell cytolysis / MGI
- increased double-negative T cell number / MGI
- decreased double-positive T cell number / MGI
- decreased B cell proliferation / MGI
- decreased T cell proliferation / MGI
- increased susceptibility to autoimmune disorder / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- decreased susceptibility to type I hypersensitivity reaction / MGI
- CNS inflammation / MGI
- increased T cell apoptosis / MGI
- abnormal T cell morphology / MGI
- increased NK cell number / MGI
- abnormal memory T cell number / MGI
- increased memory T cell number / MGI
- decreased memory T cell number / MGI
- absent T cells / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- abnormal CD4-positive T cell differentiation / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- abnormal CD8-positive, alpha-beta T cell differentiation / MGI
- increased single-positive T cell number / MGI
- decreased single-positive T cell number / MGI
- increased plasma cell number / MGI
- lymph node hyperplasia / MGI
- abnormal granulocyte differentiation / MGI
- increased dendritic cell number / MGI
- decreased B-1a cell number / MGI
- increased B-1b cell number / MGI
- decreased B-1b cell number / MGI
- decreased follicular B cell number / MGI
- increased transitional stage B cell number / MGI
- abnormal follicular B cell physiology / MGI
- decreased B-2 B cell number / MGI
- decreased mature B cell number / MGI
- abnormal B cell activation / MGI
- abnormal leukocyte morphology / MGI
- decreased gamma-delta intraepithelial T cell number / MGI
- abnormal CD4-positive, alpha-beta intraepithelial T cell morphology / MGI
- increased spleen red pulp amount / MGI
- increased spleen white pulp amount / MGI
- increased IgG2a level / MGI
- increased plasmacytoid dendritic cell number / MGI
- abnormal chemokine secretion / MGI
- decreased memory B cell number / MGI
- decreased mast cell degranulation / MGI
- abnormal intraepithelial T cell morphology / MGI
- abnormal intraepithelial T cell number / MGI
- decreased oligodendrocyte number / MGI
- increased DN3 thymocyte number / MGI
- decreased DN4 thymocyte number / MGI
- abnormal NK cell physiology / MGI
- mortality/aging / MGI
- decreased CD4-positive, alpha-beta memory T cell number / MGI
- decreased CD8-positive, alpha-beta memory T cell number / MGI
- lethality at weaning, incomplete penetrance / MGI
- increased alpha-beta T cell number / MGI
- decreased CD8-positive, naive alpha-beta T cell number / MGI
NOD.B6-Ptprcb/Orl
Status | Available to order |
EMMA ID | EM:01637 |
International strain name | NOD.B6-Ptprcb/Orl |
Alternative name | NOD.CD45.2 |
Strain type | Spontaneous |
Allele/Transgene symbol | Ptprcb |
Gene/Transgene symbol | Ptprc |
Information from provider
Provider | Francoise Lepault |
Provider affiliation | INSERM U561 - Hopital Saint Vincent de Paul |
Genetic information | NOD congenic strain for Ptprcb (CD45.2) from C57BL/6. |
Phenotypic information | No phenotypic changes detected. Diabetes incidence similar to wild-type NOD mice. |
Breeding history | NOD mice were crossed with C57BL/6 mice and backcrossed to the NOD background for more than 10 times, before brother-sister intercross. Mice are homozygous for Ptprcb (CD45.2). No breeding problem with this line. |
References | None available |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- T-B+ severe combined immunodeficiency due to CD45 deficiency / Orphanet_169157
MGI phenotypes (gene matching)
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