| Status | Available to order |
| EMMA ID | EM:00158 |
| Citation information | RRID:IMSR_EM:00158 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129S7-Prnptm1Cwe/CweCnrm |
| Alternative name | Prp-KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Prnptm1Cwe |
| Gene/Transgene symbol | Prnp |
| Provider | Adriano Aguzzi |
| Provider affiliation | Univ.Hosp.Zurich/Inst.Neuropathology |
| Genetic information | Generation of Prnp (PrP) knock-out mice. Disruption of Prnp allele of ES cells by homologous recombination. A 4.8 kb genomic sequence was replaced by neo gene under the HSV TK promoter. Homozygous breeding. |
| References |
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| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
| Animals used for archiving | homozygous males, wild-type females |
| Breeding at archiving centre | A sub-strain with the same mutation and genetic background is maintained at the repository at the Institut de Transgenose, INTRAGENE, Orleans, France: EM:05303 |
| Stage of embryos | 2-cell |
Orphanet associated rare diseases, based on orthologous gene matching
