C57BL/6N-Ets2em1(IMPC)Ics/Ics

Status

Available to order

EMMA IDEM:15788
Citation informationRRID:IMSR_EM:15788 

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International strain nameC57BL/6N-Ets2em1(IMPC)Ics/Ics
Alternative nameEts2em1(IMPC)Ics
Strain typeEndonuclease-mediated
Allele/Transgene symbolEts2em1(IMPC)Ics
Gene/Transgene symbolEts2

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis allele was generated at the Institute Clinique de la Souris by electroporating Cas9 protein and 4 RNA guides (sequences: TTGACGGCGTGCTTTCTTAG, GGACCCATGGCAGGGTTACT, GGTCATTCTGGTGTCGTCAC and ACAGACAGTTCTCGGCTCAC), which resulted in the deletion of Ets2 exon 3 (ENSMUSE00001449193; GRCm39), leading to a frameshift with a premature stop. This line is cryopreserved.
Phenotypic informationHomozygous:
NA

Heterozygous:
Viable, no obvious phenotype
Breeding historyThis line was generated on a pure C57BL/6N genetic background.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

MGI phenotypes (gene matching)
  • abnormal hair follicle orientation / MGI
  • increased curvature of guard hairs / MGI
  • increased curvature of awl hairs / MGI
  • increased curvature of zigzag hairs / MGI
  • increased curvature of auchene hairs / MGI
  • waved hair / MGI
  • curly vibrissae / MGI
  • decreased embryo size / MGI
  • absent vitelline blood vessels / MGI
  • abnormal extraembryonic tissue morphology / MGI
  • no abnormal phenotype detected / MGI
  • no phenotypic analysis / MGI
  • decreased tumor growth/size / MGI
  • abnormal trophoblast layer morphology / MGI
  • abnormal ectoplacental cone morphology / MGI
  • abnormal trophoblast giant cell morphology / MGI
  • embryonic lethality between somite formation and embryo turning, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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