- fragile skeleton / MGI
- decreased bone mineral density / MGI
- abnormal parietal bone morphology / MGI
- abnormal tooth development / MGI
- abnormal long bone metaphysis morphology / MGI
- decreased leukocyte cell number / MGI
- abnormal small intestine morphology / MGI
- abnormal spleen morphology / MGI
- small spleen / MGI
- weakness / MGI
- abnormal spinal nerve morphology / MGI
- lung hemorrhage / MGI
- decreased body size / MGI
- impaired coordination / MGI
- internal hemorrhage / MGI
- abnormal digestion / MGI
- intracranial hemorrhage / MGI
- apnea / MGI
- seizures / MGI
- abnormal tooth morphology / MGI
- abnormal muscle morphology / MGI
- abnormal thymus cortex morphology / MGI
- decreased circulating alkaline phosphatase level / MGI
- abnormal cementum morphology / MGI
- abnormal alveolar process morphology / MGI
- abnormal osteoblast morphology / MGI
- increased bone resorption / MGI
- abnormal osteoblast physiology / MGI
- cachexia / MGI
- decreased long bone epiphyseal plate size / MGI
- pale spleen / MGI
- decreased trabecular bone thickness / MGI
- abnormal blood homeostasis / MGI
- decreased total body fat amount / MGI
- increased bone trabecula number / MGI
- postnatal lethality, complete penetrance / MGI
- abnormal tooth root development / MGI
- decreased alkaline phosphatase activity / MGI
- abnormal dental pulp morphology / MGI
- decreased bone mineralization / MGI
- delayed bone mineralization / MGI
- thin parietal bone / MGI
- abnormal dentin mineralization / MGI
- abnormal cementum mineralization / MGI
- abnormal odontoblast morphology / MGI
- abnormal tooth root morphology / MGI
- short tooth root / MGI
- abnormal acellular cementum morphology / MGI
- abnormal cellular cementum morphology / MGI
C57BL/6NCrl-Alplem1(IMPC)Ccpcz/Ph
Status | Under development - register interest |
EMMA ID | EM:15738 |
International strain name | C57BL/6NCrl-Alplem1(IMPC)Ccpcz/Ph |
Alternative name | |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Alplem1(IMPC)Ccpcz |
Gene/Transgene symbol | Alpl |
Information from provider
Provider | Institute of Molecular Genetics |
Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Infantile hypophosphatasia / Orphanet_247651
- Odontohypophosphatasia / Orphanet_247685
- Adult hypophosphatasia / Orphanet_247676
- Childhood-onset hypophosphatasia / Orphanet_247667
- Perinatal lethal hypophosphatasia / Orphanet_247623
- Prenatal benign hypophosphatasia / Orphanet_247638
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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