- decreased bone marrow cell number / MGI
- decreased cell proliferation / MGI
- abnormal immune system morphology / MGI
- small spleen / MGI
- abnormal thymus morphology / MGI
- small thymus / MGI
- decreased thymocyte number / MGI
- abnormal immune system cell morphology / MGI
- abnormal lymphocyte cell number / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- abnormal diencephalon morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- postnatal growth retardation / MGI
- abnormal immune system physiology / MGI
- arrested B cell differentiation / MGI
- decreased IgG level / MGI
- decreased IgM level / MGI
- decreased IgA level / MGI
- arrested T cell differentiation / MGI
- abnormal T cell activation / MGI
- intestinal inflammation / MGI
- liver inflammation / MGI
- reduced fertility / MGI
- increased cellular sensitivity to gamma-irradiation / MGI
- increased T cell derived lymphoma incidence / MGI
- premature death / MGI
- abnormal B cell differentiation / MGI
- abnormal T cell differentiation / MGI
- abnormal lymphopoiesis / MGI
- abnormal proerythroblast morphology / MGI
- decreased immunoglobulin level / MGI
- abnormal immune system organ morphology / MGI
- increased neuron apoptosis / MGI
- chromosome breakage / MGI
- spontaneous chromosome breakage / MGI
- induced chromosome breakage / MGI
- abnormal striatum morphology / MGI
- decreased fetal size / MGI
- increased cellular sensitivity to ionizing radiation / MGI
- increased anti-double stranded DNA antibody level / MGI
- decreased hematopoietic stem cell number / MGI
- increased anti-chromatin antibody level / MGI
- abnormal regulatory T cell morphology / MGI
- decreased spleen weight / MGI
- decreased thymus weight / MGI
- decreased lymphocyte cell number / MGI
- decreased B cell number / MGI
- decreased double-negative T cell number / MGI
- decreased double-positive T cell number / MGI
- decreased T cell proliferation / MGI
- abnormal brainstem morphology / MGI
- cellular phenotype / MGI
- hematopoietic system phenotype / MGI
- abnormal cell physiology / MGI
- thin cerebral cortex / MGI
- increased medulloblastoma incidence / MGI
- increased T cell apoptosis / MGI
- abnormal DNA repair / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- abnormal B cell activation / MGI
- decreased IgG2b level / MGI
- decreased IgG3 level / MGI
- decreased interferon-gamma secretion / MGI
- decreased interleukin-13 secretion / MGI
- abnormal T cell receptor V(D)J recombination / MGI
- abnormal T cell receptor beta chain V(D)J recombination / MGI
- chromosomal instability / MGI
- increased colon adenocarcinoma incidence / MGI
- decreased splenocyte number / MGI
- prenatal lethality, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- decreased fibroblast proliferation / MGI
- increased forebrain apoptosis / MGI
- increased spinal cord apoptosis / MGI
C57BL/6NCrl-Lig4em1(IMPC)Ccpcz/Ph
Status | Under development - register interest |
EMMA ID | EM:15733 |
International strain name | C57BL/6NCrl-Lig4em1(IMPC)Ccpcz/Ph |
Alternative name | |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Lig4em1(IMPC)Ccpcz |
Gene/Transgene symbol | Lig4 |
Information from provider
Provider | Institute of Molecular Genetics |
Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Omenn syndrome / Orphanet_39041
- LIG4 syndrome / Orphanet_99812
- Dubowitz syndrome / Orphanet_235
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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