IMPC phenotypes (gene matching)
- preweaning lethality, complete penetrance / IMPC
C57BL/6NCrl-Fynem1(IMPC)Ccpcz/Ph
| Status | Under development - register interest |
| EMMA ID | EM:15728 |
| International strain name | C57BL/6NCrl-Fynem1(IMPC)Ccpcz/Ph |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Fynem1(IMPC)Ccpcz |
| Gene/Transgene symbol | Fyn |
Information from provider
| Provider | Institute of Molecular Genetics |
| Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased corpus callosum size / MGI
- abnormal stratification in cerebral cortex / MGI
- abnormal hippocampus morphology / MGI
- abnormal dentate gyrus morphology / MGI
- abnormal hippocampus layer morphology / MGI
- abnormal olfactory bulb morphology / MGI
- abnormal hypothalamus morphology / MGI
- abnormal somatosensory cortex morphology / MGI
- abnormal myelination / MGI
- small seminiferous tubules / MGI
- abnormal optic nerve morphology / MGI
- abnormal pup retrieval / MGI
- abnormal maternal nurturing / MGI
- abnormal suckling behavior / MGI
- abnormal spatial learning / MGI
- reduced long term potentiation / MGI
- abnormal startle reflex / MGI
- audiogenic seizures / MGI
- abnormal immune cell physiology / MGI
- abnormal T cell activation / MGI
- increased dopamine level / MGI
- abnormal olfaction / MGI
- abnormal seminiferous tubule morphology / MGI
- abnormal T cell physiology / MGI
- abnormal macrophage physiology / MGI
- abnormal eosinophil physiology / MGI
- decreased IgE level / MGI
- increased IgM level / MGI
- oligozoospermia / MGI
- abnormal excitatory postsynaptic potential / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- increased fear-related response / MGI
- abnormal thymocyte activation / MGI
- enhanced passive avoidance behavior / MGI
- increased susceptibility to experimental autoimmune uveoretinitis / MGI
- decreased testis weight / MGI
- abnormal T cell clonal deletion / MGI
- decreased T cell number / MGI
- abnormal T cell proliferation / MGI
- decreased T cell proliferation / MGI
- abnormal CD4-positive, alpha-beta T cell physiology / MGI
- increased susceptibility to type I hypersensitivity reaction / MGI
- abnormal hippocampus pyramidal cell layer / MGI
- decreased gamma-delta T cell number / MGI
- increased IgG2a level / MGI
- increased tumor necrosis factor secretion / MGI
- decreased interferon-gamma secretion / MGI
- abnormal interleukin secretion / MGI
- decreased interleukin-2 secretion / MGI
- abnormal interleukin-4 secretion / MGI
- increased interleukin-5 secretion / MGI
- abnormal chemokine level / MGI
- enhanced behavioral response to alcohol / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- abnormal hippocampus pyramidal cell morphology / MGI
- increased hippocampus pyramidal cell number / MGI
- ectopic hippocampus pyramidal cells / MGI
- increased serotonin level / MGI
- abnormal NK cell physiology / MGI
- abnormal Sertoli cell barrier morphology / MGI
- prolonged circadian behavior period / MGI
- abnormal locomotor circadian rhythm / MGI