IMPC phenotypes (gene matching)
C57BL/6J-Cd19em1H/H
| Status | Available to order |
| EMMA ID | EM:15701 |
| International strain name | C57BL/6J-Cd19em1H/H |
| Alternative name | C57BL/6J- Cd19 |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Cd19em1H |
| Gene/Transgene symbol | Cd19 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | As reported by Mouse Genome Informatics, CD19, a protein coding gene encodes CD19 molecule. This strain carries a knock in of Cebpe CDS-T2A-eGFP SV40 into the N-terminus of Cd19 made using CRISPR/Cas9 gene editing via pronuclear injection into 1-cell stage embryos. |
| Phenotypic information | Homozygous:To be determinedHeterozygous:To be determined |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Common variable immunodeficiency / Orphanet_1572
MGI phenotypes (gene matching)
- decreased neutrophil cell number / MGI
- demyelination / MGI
- thick dermal layer / MGI
- abnormal humoral immune response / MGI
- decreased IgM level / MGI
- decreased IgA level / MGI
- abnormal B cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal B cell physiology / MGI
- abnormal immunoglobulin level / MGI
- decreased IgE level / MGI
- decreased anti-nuclear antigen antibody level / MGI
- decreased anti-double stranded DNA antibody level / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased B-1 B cell number / MGI
- decreased B cell number / MGI
- decreased B cell proliferation / MGI
- increased susceptibility to injury / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- absent spleen germinal center / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased IgG2b level / MGI
- decreased IgG3 level / MGI
- decreased circulating tumor necrosis factor level / MGI
- decreased tumor necrosis factor secretion / MGI
- increased interferon-gamma secretion / MGI
- decreased circulating interferon-gamma level / MGI
- decreased circulating interleukin-10 level / MGI
- decreased circulating interleukin-6 level / MGI
- decreased circulating interleukin-4 level / MGI
- decreased interleukin-10 secretion / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- skin fibrosis / MGI