IMPC phenotypes (gene matching)
C57BL/6J-Cd19em1H/H
| Status | Available to order |
| EMMA ID | EM:15701 |
| Citation information | RRID:IMSR_EM:15701 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6J-Cd19em1H/H |
| Alternative name | C57BL/6J- Cd19 |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Cd19em1H |
| Gene/Transgene symbol | Cd19 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | As reported by Mouse Genome Informatics, CD19, a protein coding gene encodes CD19 molecule. This strain carries a knock in of Cebpe CDS-T2A-eGFP SV40 into the N-terminus of Cd19 made using CRISPR/Cas9 gene editing via pronuclear injection into 1-cell stage embryos. |
| Phenotypic information | Homozygous:To be determinedHeterozygous:To be determined |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Common variable immunodeficiency / Orphanet_1572
MGI phenotypes (gene matching)
- decreased neutrophil cell number / MGI
- demyelination / MGI
- thick dermal layer / MGI
- abnormal humoral immune response / MGI
- decreased IgM level / MGI
- decreased IgA level / MGI
- abnormal B cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal B cell physiology / MGI
- abnormal immunoglobulin level / MGI
- decreased IgE level / MGI
- decreased anti-nuclear antigen antibody level / MGI
- decreased anti-double stranded DNA antibody level / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased B-1 B cell number / MGI
- decreased B cell number / MGI
- decreased B cell proliferation / MGI
- increased susceptibility to injury / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- absent spleen germinal center / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased IgG2b level / MGI
- decreased IgG3 level / MGI
- decreased circulating tumor necrosis factor level / MGI
- decreased tumor necrosis factor secretion / MGI
- increased interferon-gamma secretion / MGI
- decreased circulating interferon-gamma level / MGI
- decreased circulating interleukin-10 level / MGI
- decreased circulating interleukin-6 level / MGI
- decreased circulating interleukin-4 level / MGI
- decreased interleukin-10 secretion / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- skin fibrosis / MGI