IMPC phenotypes (gene matching)
C57BL/6J-Itpr1em2H/H
| Status | Available to order |
| EMMA ID | EM:15628 |
| International strain name | C57BL/6J-Itpr1em2H/H |
| Alternative name | C57BL/6J-Itpr1em2H/H |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Itpr1em2H |
| Gene/Transgene symbol | Itpr1 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | Itpr1, a protein coding gene, codes for inositol 1,4,5-triphosphate receptor type 1 and its human ortholog ITPR1 is associated with Gillespie syndrome, spinocerebellar ataxia type 15 and spinocerebellar ataxia type 29 in humans. This is a CRISPR/Cas9 induced mutation creating a series of point mutations; G2545R in exon ENSMUSE00000407938 of ITPR1. The stock was generated at MRC Harwell via microinjection of CRISPR/Cas9 reagents into 1-cell stage embryos. |
| Phenotypic information | Homozygous:To be determinedHeterozygous:To be determined |
| Breeding history | crossed once to C57BL/6J after electroporation. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |