IMPC phenotypes (gene matching)
C57BL/6J-Itpr1em2H/H
| Status | Available to order |
| EMMA ID | EM:15628 |
| Citation information | RRID:IMSR_EM:15628 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6J-Itpr1em2H/H |
| Alternative name | C57BL/6J-Itpr1em2H/H |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Itpr1em2H |
| Gene/Transgene symbol | Itpr1 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | Itpr1, a protein coding gene, codes for inositol 1,4,5-triphosphate receptor type 1 and its human ortholog ITPR1 is associated with Gillespie syndrome, spinocerebellar ataxia type 15 and spinocerebellar ataxia type 29 in humans. This is a CRISPR/Cas9 induced mutation creating a series of point mutations; G2545R in exon ENSMUSE00000407938 of ITPR1. The stock was generated at MRC Harwell via microinjection of CRISPR/Cas9 reagents into 1-cell stage embryos. |
| Phenotypic information | Homozygous:To be determinedHeterozygous:To be determined |
| Breeding history | crossed once to C57BL/6J after electroporation. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |