IMPC phenotypes (gene matching)
C57BL/6N-Kif5ctm1.2Ics/Ics
| Status | Available to order |
| EMMA ID | EM:15621 |
| Citation information | RRID:IMSR_EM:15621 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Kif5ctm1.2Ics/Ics |
| Alternative name | Kif5ctm1.2Ics (G4563) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Kif5ctm1.2Ics |
| Gene/Transgene symbol | Kif5c |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | This line was obtained by modification of BD10 in house-derived C57BL/6N embryonic stem cells.The A to T mutation (codon GAA to GTA) leading to the E237V point mutation has been inserted in exon 8 (ENSMUSE00000162501) and allows the expression of the mutated protein. The same exon 8 was also floxed so that the excision of this critical exon will lead to a knock-out after cre recombinase-mediated excision in between the two LoxP sites. The flipped NeoR cassette was removed by breeding the male chimeras with flp recombinase deleter females. The knock-out allele was obtained after an additional breeding of the conditional allele with a cre recombinase deleter line. The line was generated on a pure C57BL/6N inbred genetic background. For detailed information on the genetic description of this strain, please have a look at this report. |
| Phenotypic information | Homozygous:Homozygous mice are subviableHeterozygous:DOI: 10.3390/biomedicines10123148 |
| Breeding history | Inbred C57BL/6N |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
Literature references
- Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.;Meziane Hamid, Birling Marie-Christine, Wendling Olivia, Leblanc Sophie, Dubos Aline, Selloum Mohammed, Pavlovic Guillaume, Sorg Tania, Kalscheuer Vera M, Billuart Pierre, Laumonnier Frédéric, Chelly Jamel, van Bokhoven Hans, Herault Yann, ;2022;Biomedicines;10;; 36551904