C57BL/6NTac-Tlr2em2H/H
| Status | Available to order |
| EMMA ID | EM:15588 |
| International strain name | C57BL/6NTac-Tlr2em2H/H |
| Alternative name | C57BL/6NTac-Tlr2em2H/H |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Tlr2em2H |
| Gene/Transgene symbol | Tlr2 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | As reported by Mouse Genome Informatics, Tlr2, a protein coding gene, codes for toll like receptor 2. It is associated with diseases including but not limited to breast, colorectal, and prostate cancer, diabetes mellitus and meningococcal meningitis. This strain is a floxed mutant of existing line (C57BL/6NTac-Tlr2em1H/H). Floxed allele (ENSMUSE00000441912 of Tlr2). A conditional knock-out was made by floxing critical exon by CRISPR/Cas9 gene editing via cytoplasmic microinjection into 1-cell stage embryo. |
| Phenotypic information | Homozygous:To be confirmedHeterozygous:To be confirmed |
| Breeding history | Incepient congenic on maintained background |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |