C57BL/6NTac-Cxcr4em2H/H
| Status | Available to order |
| EMMA ID | EM:15585 |
| International strain name | C57BL/6NTac-Cxcr4em2H/H |
| Alternative name | C57BL/6NTac-Cxcr4em2H/H |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Cxcr4em2H |
| Gene/Transgene symbol | Cxcr4 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mammalian Genetics Unit, Mary Lyon Centre at MRC Harwell |
| Genetic information | As reported by Mouse Genome Informatics, Cxcr4, a protein coding gene, codes for C-X-C chemokine receptor 4 and is associated with WHIM syndrome, cardiomyopathy and congestive heart failure in both mice and humans. ERT2 cassette knock-in to the existing Cxcr4-CRE-EM1-B6N allele, made by CRISPR/Cas9 gene editing via pronuclear injection of reagents into 1-cell stage embryo. |
| Phenotypic information | Homozygous:To be confirmedHeterozygous:To be confirmed |
| Breeding history | Incepient congenic on maintained background |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- WHIM syndrome / Orphanet_51636