C57BL/6NTac-Cxcr4em2H/H

Status

Available to order

EMMA IDEM:15585
Citation informationRRID:IMSR_EM:15585 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Cxcr4em2H/H
Alternative nameC57BL/6NTac-Cxcr4em2H/H
Strain typeEndonuclease-mediated
Allele/Transgene symbolCxcr4em2H
Gene/Transgene symbolCxcr4

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationAs reported by Mouse Genome Informatics, Cxcr4, a protein coding gene, codes for C-X-C chemokine receptor 4 and is associated with WHIM syndrome, cardiomyopathy and congestive heart failure in both mice and humans. ERT2 cassette knock-in to the existing Cxcr4-CRE-EM1-B6N allele, made by CRISPR/Cas9 gene editing via pronuclear injection of reagents into 1-cell stage embryo.
Phenotypic informationHomozygous:
To be confirmed

Heterozygous:
To be confirmed
Breeding historyIncepient congenic on maintained background
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • abnormal blood vessel morphology / IMPC
  • microphthalmia / IMPC
  • increased lymphocyte cell number / IMPC
  • abnormal placenta morphology / IMPC
  • abnormal kidney morphology / IMPC
  • abnormal limb morphology / IMPC
  • increased leukocyte cell number / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • abnormal skin morphology / IMPC
  • embryonic growth retardation / IMPC
  • enlarged spleen / IMPC
  • increased monocyte cell number / IMPC
  • abnormal placenta size / IMPC
  • abnormal eyelid morphology / IMPC
  • cataract / IMPC
  • enlarged testis / IMPC
  • enlarged kidney / IMPC
  • abnormal testis morphology / IMPC
  • abnormal vitreous body morphology / IMPC
  • abnormal spleen morphology / IMPC
  • persistence of hyaloid vascular system / IMPC
  • decreased circulating creatinine level / IMPC
  • edema / IMPC

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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