IMPC phenotypes (gene matching)
C57BL/6N-Fshrtm1.2(cre)Ics/Ics
| Status | Available to order |
| EMMA ID | EM:15550 |
| International strain name | C57BL/6N-Fshrtm1.2(cre)Ics/Ics |
| Alternative name | Fshrtm1.2(cre)Ics |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Fshrtm1.2(cre)Ics |
| Gene/Transgene symbol | Fshr |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | This line was obtained by crossing Fshrtm1.1(cre/ERT2)Ics animals with the C57BL/6NTac-Gt(ROSA)26Sor-tm2(CAG-flpo,-EYFP)Ics flp ubiquitous deleter (EMMA strain ID EM:05490), resulting in an IRES-cre-F3 sequence located into the 3' UTR region of the Fshr gene. The pure C57BL/6N background was maintained for all breeding steps. Efficiency of deletion was confirmed by crossing this line with the fluorescent reporter of cre expression Gt(ROSA)26Sor-tm4(ACTB-tdTomato,-EGFP)Luo. A specific EGFP signal was observed in the ovaries and no signal was observed in the control organ (liver). Analysis of mRNA expression showed that tm1.2 allele (cre probe) mRNA is also expressed at an expected level in the ovaries. For detailed information on the genetic description of this strain, please have a look at this report. |
| Phenotypic information | Homozygous:NAHeterozygous:NA |
| Breeding history | C57BL/6N inbred (3 generations). |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- 46,XX gonadal dysgenesis / Orphanet_243
MGI phenotypes (gene matching)
- abnormal abdominal fat pad morphology / MGI
- decreased bone mineral density / MGI
- kyphosis / MGI
- enlarged spleen / MGI
- hippocampal neuron degeneration / MGI
- abnormal dentate gyrus morphology / MGI
- abnormal uterus morphology / MGI
- abnormal ovary morphology / MGI
- small ovary / MGI
- impaired ovarian folliculogenesis / MGI
- abnormal ovarian folliculogenesis / MGI
- absent mature ovarian follicles / MGI
- absent corpus luteum / MGI
- abnormal vagina epithelium morphology / MGI
- abnormal vagina orifice morphology / MGI
- vagina atresia / MGI
- small testis / MGI
- small seminiferous tubules / MGI
- abnormal spermatogenesis / MGI
- small seminal vesicle / MGI
- increased body weight / MGI
- obese / MGI
- weight loss / MGI
- increased anxiety-related response / MGI
- hunched posture / MGI
- anemia / MGI
- increased circulating follicle stimulating hormone level / MGI
- increased circulating luteinizing hormone level / MGI
- reduced male fertility / MGI
- reduced female fertility / MGI
- female infertility / MGI
- abnormal estrous cycle / MGI
- abnormal spermiogenesis / MGI
- decreased litter size / MGI
- delayed sexual maturation / MGI
- ovary cysts / MGI
- abnormal seminiferous tubule morphology / MGI
- neurodegeneration / MGI
- long gestation period / MGI
- abnormal epididymis morphology / MGI
- small uterus / MGI
- abnormal caput epididymis morphology / MGI
- abnormal corpus epididymis morphology / MGI
- asthenozoospermia / MGI
- increased follicle recruitment / MGI
- abnormal spermatogonia proliferation / MGI
- oligozoospermia / MGI
- absent ovarian follicles / MGI
- decreased circulating testosterone level / MGI
- increased circulating testosterone level / MGI
- abnormal testes secretion / MGI
- abnormal ovarian secretion / MGI
- increased thigmotaxis / MGI
- abnormal thoracic vertebrae morphology / MGI
- increased pre-B cell number / MGI
- calcinosis / MGI
- astrocytosis / MGI
- abnormal ovary physiology / MGI
- enlarged clitoris / MGI
- increased ovarian carcinoma incidence / MGI
- pallor / MGI
- premature aging / MGI
- abnormal testis development / MGI
- abnormal uterine environment / MGI
- abnormal sperm physiology / MGI
- absent oocytes / MGI
- ovary atrophy / MGI
- ovary hemorrhage / MGI
- abnormal testis size / MGI
- decreased testis weight / MGI
- decreased ovary weight / MGI
- uterus atrophy / MGI
- vagina atrophy / MGI
- uterine hemorrhage / MGI
- increased uterus weight / MGI
- decreased uterus weight / MGI
- enlarged uterus / MGI
- decreased seminal vesicle weight / MGI
- decreased epididymis weight / MGI
- small epididymis / MGI
- abnormal epididymis epithelium morphology / MGI
- abnormal thrombosis / MGI
- increased follicle stimulating hormone level / MGI
- increased luteinizing hormone level / MGI
- cachexia / MGI
- decreased circulating estradiol level / MGI
- decreased circulating progesterone level / MGI
- Sertoli cell hypoplasia / MGI
- teratozoospermia / MGI
- abnormal enzyme/coenzyme activity / MGI
- increased apoptosis / MGI
- abnormal female germ cell morphology / MGI
- abnormal male germ cell morphology / MGI
- abnormal spermatogonia morphology / MGI
- abnormal spermatid morphology / MGI
- increased ovary tumor incidence / MGI
- increased gonadotroph cell number / MGI
- increased thyrotroph cell number / MGI
- abnormal granulosa cell morphology / MGI
- anovulation / MGI
- abnormal ovarian follicle number / MGI
- abnormal sperm flagellum morphology / MGI
- increased total fat pad weight / MGI
- delayed male fertility / MGI
- delayed female fertility / MGI
- decreased vagina weight / MGI
- early vaginal opening / MGI
- early reproductive senescence / MGI
- prolonged estrous cycle / MGI
- absent estrous cycle / MGI
- prolonged diestrus / MGI
- abnormal estrus / MGI
- thin uterus / MGI
- uterus cysts / MGI
- myometrium hypoplasia / MGI
- oocyte degeneration / MGI
- abnormal endometrial gland morphology / MGI
- uterus adenomyosis / MGI
- increased uterus tumor incidence / MGI
- abnormal sperm head morphology / MGI
- detached acrosome / MGI
- abnormal sperm nucleus morphology / MGI
- enlarged sperm head / MGI
- kinked sperm flagellum / MGI
- small caput epididymis / MGI
- enlarged endometrial glands / MGI
- polyovular ovarian follicle / MGI
- abnormal sperm axoneme morphology / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- decreased primary ovarian follicle number / MGI
- abnormal seminiferous tubule epithelium morphology / MGI
- adenohypophysis hyperplasia / MGI
- decreased femur weight / MGI