C57BL/6N-Ppp4cem1(IMPC)Ics/Ics

Status

Available to order

EMMA IDEM:15508
International strain nameC57BL/6N-Ppp4cem1(IMPC)Ics/Ics
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolPpp4cem1(IMPC)Ics
Gene/Transgene symbolPpp4c

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
References
  • Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein.;Kretz Perrine F, Wagner Christel, Mikhaleva Anna, Montillot Charlotte, Hugel Sylvain, Morella Ilaria, Kannan Meghna, Fischer Marie-Christine, Milhau Maxence, Yalcin Ipek, Brambilla Riccardo, Selloum Mohammed, Herault Yann, Reymond Alexandre, Collins Stephan C, Yalcin Binnaz, ;2023;Genome biology;24;261; 37968726

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

IMPC phenotypes (allele matching)
  • abnormal contextual conditioning behavior / IMPC
  • increased heart weight / IMPC
  • increased circulating bilirubin level / IMPC
IMPC phenotypes (gene matching)
  • increased heart weight / IMPC
  • increased circulating bilirubin level / IMPC
  • abnormal contextual conditioning behavior / IMPC

Literature references

  • Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein.;Kretz Perrine F, Wagner Christel, Mikhaleva Anna, Montillot Charlotte, Hugel Sylvain, Morella Ilaria, Kannan Meghna, Fischer Marie-Christine, Milhau Maxence, Yalcin Ipek, Brambilla Riccardo, Selloum Mohammed, Herault Yann, Reymond Alexandre, Collins Stephan C, Yalcin Binnaz, ;2023;Genome biology;24;261; 37968726

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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