C57BL/6NCrl-Gsnem1(IMPC)Hmgu/Ieg

Status

Available to order

EMMA IDEM:15474
International strain nameC57BL/6NCrl-Gsnem1(IMPC)Hmgu/Ieg
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolGsnem1(IMPC)Hmgu
Gene/Transgene symbolGsn

Information from provider

Provider Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6N

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • osteopetrosis / MGI
  • increased leukocyte cell number / MGI
  • increased neutrophil cell number / MGI
  • abnormal branching of the mammary ductal tree / MGI
  • abnormal skeleton physiology / MGI
  • abnormal osteoclast physiology / MGI
  • abnormal immune system physiology / MGI
  • decreased inflammatory response / MGI
  • premature death / MGI
  • abnormal nervous system electrophysiology / MGI
  • abnormal pulmonary circulation / MGI
  • abnormal bone remodeling / MGI
  • abnormal long bone epiphyseal plate morphology / MGI
  • increased vascular permeability / MGI
  • increased susceptibility to ischemic brain injury / MGI
  • increased compact bone thickness / MGI
  • abnormal long bone diaphysis morphology / MGI
  • abnormal wound healing / MGI
  • abnormal platelet physiology / MGI
  • abnormal skeleton morphology / MGI
  • increased bleeding time / MGI
  • increased cerebral infarction size / MGI
  • abnormal mammary gland growth during pregnancy / MGI
  • abnormal osteoclast differentiation / MGI
  • impaired neutrophil recruitment / MGI
  • impaired neutrophil chemotaxis / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • abnormal mammary duct terminal end bud morphology / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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