C57BL/6NCrl-Vdrem1(IMPC)Hmgu/Ieg

Status

Available to order

EMMA IDEM:15467
International strain nameC57BL/6NCrl-Vdrem1(IMPC)Hmgu/Ieg
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolVdrem1(IMPC)Hmgu
Gene/Transgene symbolVdr

Information from provider

Provider Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6N

Disease and phenotype information

IMPC phenotypes (allele matching)
  • abnormal coat/ hair morphology / IMPC
  • abnormal head morphology / IMPC
  • tremors / IMPC
  • abnormal locomotor behavior / IMPC
  • decreased locomotor activity / IMPC
  • abnormal gait / IMPC
  • decreased startle reflex / IMPC
  • abnormal coat/hair pigmentation / IMPC
  • decreased vertical activity / IMPC
  • short tibia / IMPC
  • increased prepulse inhibition / IMPC
  • decreased grip strength / IMPC
IMPC phenotypes (gene matching)
  • abnormal gait / IMPC
  • decreased locomotor activity / IMPC
  • abnormal coat/hair pigmentation / IMPC
  • decreased startle reflex / IMPC
  • abnormal coat/ hair morphology / IMPC
  • abnormal locomotor behavior / IMPC
  • short tibia / IMPC
  • abnormal head morphology / IMPC
  • decreased vertical activity / IMPC
  • tremors / IMPC
  • decreased grip strength / IMPC
  • increased prepulse inhibition / IMPC
MGI phenotypes (gene matching)
  • increased bone mineral density / MGI
  • decreased bone mineral density / MGI
  • abnormal trabecular bone morphology / MGI
  • abnormal long bone metaphysis morphology / MGI
  • decreased compact bone thickness / MGI
  • abnormal long bone hypertrophic chondrocyte zone / MGI
  • abnormal chondrocyte morphology / MGI
  • decreased circulating calcium level / MGI
  • decreased circulating phosphate level / MGI
  • hypertension / MGI
  • abnormal coat/ hair morphology / MGI
  • abnormal hair follicle morphology / MGI
  • alopecia / MGI
  • short snout / MGI
  • abnormal intestinal epithelium morphology / MGI
  • abnormal colon morphology / MGI
  • abnormal intestinal mucosa morphology / MGI
  • intestinal ulcer / MGI
  • abnormal tibia morphology / MGI
  • abnormal femur morphology / MGI
  • thymus hyperplasia / MGI
  • abnormal female reproductive system morphology / MGI
  • uterus hypoplasia / MGI
  • absent mature ovarian follicles / MGI
  • abnormal male reproductive system morphology / MGI
  • abnormal spermatogenesis / MGI
  • dermatitis / MGI
  • abnormal epidermis stratum granulosum morphology / MGI
  • mixed cellular infiltration to dermis / MGI
  • dermal cysts / MGI
  • decreased body weight / MGI
  • weight loss / MGI
  • decreased body size / MGI
  • sparse vibrissae / MGI
  • hypoactivity / MGI
  • impaired coordination / MGI
  • short stride length / MGI
  • abnormal response to new environment / MGI
  • abnormal startle reflex / MGI
  • cardiac hypertrophy / MGI
  • postnatal growth retardation / MGI
  • increased circulating follicle stimulating hormone level / MGI
  • increased circulating luteinizing hormone level / MGI
  • polyuria / MGI
  • ear inflammation / MGI
  • intestinal inflammation / MGI
  • reduced male fertility / MGI
  • reduced female fertility / MGI
  • male infertility / MGI
  • female infertility / MGI
  • abnormal estrous cycle / MGI
  • abnormal gametogenesis / MGI
  • premature death / MGI
  • abnormal limb bone morphology / MGI
  • abnormal fertility/fecundity / MGI
  • abnormal fibula morphology / MGI
  • abnormal macrophage physiology / MGI
  • asthenozoospermia / MGI
  • oligozoospermia / MGI
  • decreased vertical activity / MGI
  • short tibia / MGI
  • increased heart weight / MGI
  • abnormal bone mineralization / MGI
  • increased circulating parathyroid hormone level / MGI
  • increased circulating alkaline phosphatase level / MGI
  • short femur / MGI
  • enlarged parathyroid gland / MGI
  • rickets / MGI
  • cardiac fibrosis / MGI
  • abnormal locomotor activation / MGI
  • increased circulating renin level / MGI
  • increased width of hypertrophic chondrocyte zone / MGI
  • epidermal cyst / MGI
  • increased activity of parathyroid / MGI
  • abnormal response to vitamins / MGI
  • abnormal hair follicle development / MGI
  • abnormal bone structure / MGI
  • increased left ventricle weight / MGI
  • abnormal skin development / MGI
  • abnormal nitric oxide homeostasis / MGI
  • abnormal myocardial fiber physiology / MGI
  • increased susceptibility to autoimmune diabetes / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • abnormal large intestine crypts of Lieberkuhn morphology / MGI
  • increased testis weight / MGI
  • decreased uterus weight / MGI
  • increased thymus weight / MGI
  • decreased regulatory T cell number / MGI
  • increased osteoblast cell number / MGI
  • decreased susceptibility to parasitic infection / MGI
  • abnormal glucose tolerance / MGI
  • cardiovascular system phenotype / MGI
  • immune system phenotype / MGI
  • abnormal fat-soluble vitamin level / MGI
  • increased urine calcium level / MGI
  • increased circulating atrial natriuretic factor / MGI
  • abnormal renin activity / MGI
  • increased renin activity / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • increased bone mass / MGI
  • increased urine potassium level / MGI
  • abnormal mineral homeostasis / MGI
  • increased systemic arterial diastolic blood pressure / MGI
  • increased systemic arterial systolic blood pressure / MGI
  • decreased systemic arterial systolic blood pressure / MGI
  • increased urine sodium level / MGI
  • increased circulating angiotensinogen level / MGI
  • abnormal T cell number / MGI
  • disorganized long bone epiphyseal plate / MGI
  • increased long bone epiphyseal plate size / MGI
  • abnormal dendritic cell differentiation / MGI
  • abnormal bone ossification / MGI
  • slow postnatal weight gain / MGI
  • increased susceptibility to induced colitis / MGI
  • abnormal interleukin-1 secretion / MGI
  • decreased interleukin-6 secretion / MGI
  • abnormal chemokine secretion / MGI
  • abnormal interleukin level / MGI
  • abnormal tumor necrosis factor level / MGI
  • decreased prepulse inhibition / MGI
  • dilated seminiferous tubules / MGI
  • decreased splenocyte proliferation / MGI
  • abnormal blood homeostasis / MGI
  • abnormal urine homeostasis / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • abnormal macrophage chemotaxis / MGI
  • integument phenotype / MGI
  • increased trabecular bone volume / MGI
  • increased osteoid volume / MGI
  • decreased intestinal calcium absorption / MGI
  • abnormal vitamin D level / MGI
  • increased fluid intake / MGI
  • flat face / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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