IMPC phenotypes (gene matching)
- decreased body weight / IMPC
B6J.Cg-Atp5if1tm1-(EUCOMM)Wtsi CD4-cre/Cnbc
| Status | Available to order |
| EMMA ID | EM:15299 |
| Citation information | RRID:IMSR_EM:15299 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6J.Cg-Atp5if1tm1-(EUCOMM)Wtsi CD4-cre/Cnbc |
| Alternative name | CD4-Atp5if1-KO; Knockout of IF1 in CD4 T lymphocytes |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Atpif1tm1-(EUCOMM)Wtsi |
| Gene/Transgene symbol | Atp5if1 |
Information from provider
| Provider | José M Cuezva |
| Provider affiliation | Centro de Biología Molecular, Universidad Autónoma de Madrid |
| Genetic information | We used the Atp5if1-floxed mouse generated and described in our PLoS Biol 2021 publication (doi.org/10.1371/journal.pbio.3001252), crossed with mice expressing cre recombinase under the CD4 promoter, producing mice with deleted Atp5if1 (IF1) in CD4+ and CD8+ T lymphocytes. |
| Phenotypic information | Homozygous:None, except when stressed by infection.Heterozygous:Not studied. |
| Breeding history | 6-7 generations in C57BL/6J. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J males |
Disease and phenotype information
Literature references
- Ablation of Atp5if1 impairs metabolic reprogramming and proliferation of T lymphocytes and compromises mouse survival.;Romero-Carramiñana Inés, Dominguez-Zorita Sonia, Esparza-Moltó Pau B, Cuezva José M, ;2024;iScience;27;109863; 38799559