IMPC phenotypes (gene matching)
- decreased body weight / IMPC
B6J.Cg-Atp5if1tm1-(EUCOMM)Wtsi CD4-cre/Cnbc
| Status | Available to order |
| EMMA ID | EM:15299 |
| International strain name | B6J.Cg-Atp5if1tm1-(EUCOMM)Wtsi CD4-cre/Cnbc |
| Alternative name | CD4-Atp5if1-KO; Knockout of IF1 in CD4 T lymphocytes |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Atpif1tm1-(EUCOMM)Wtsi |
| Gene/Transgene symbol | Atp5if1 |
Information from provider
| Provider | José M Cuezva |
| Provider affiliation | Centro de Biología Molecular, Universidad Autónoma de Madrid |
| Genetic information | We used the Atp5if1-floxed mouse generated and described in our PLoS Biol 2021 publication (doi.org/10.1371/journal.pbio.3001252), crossed with mice expressing cre recombinase under the CD4 promoter, producing mice with deleted Atp5if1 (IF1) in CD4+ and CD8+ T lymphocytes. |
| Phenotypic information | Homozygous:None, except when stressed by infection.Heterozygous:Not studied. |
| Breeding history | 6-7 generations in C57BL/6J. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J |
Disease and phenotype information
Literature references
- Ablation of Atp5if1 impairs metabolic reprogramming and proliferation of T lymphocytes and compromises mouse survival.;Romero-Carramiñana Inés, Dominguez-Zorita Sonia, Esparza-Moltó Pau B, Cuezva José M, ;2024;iScience;27;109863; 38799559