STOCK Slc34a2tm-Nhch Tg(Vil1-cre)20Syr/Orl
| Status | Available to order |
| EMMA ID | EM:15297 |
| International strain name | STOCK Slc34a2tm-Nhch Tg(Vil1-cre)20Syr/Orl |
| Alternative name | B6N.Cg-Tg(Vil1-cre)20Syr/J (#033019) x B6;129-Slc34a2 tm1Nhch; Short name: NaPillb-villin |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Slc34a2tm-Nhch, Tg(Vil1-cre)20Syr |
| Gene/Transgene symbol | Slc34a2, Tg(Vil1-cre)20Syr |
Information from provider
| Provider | Nati Hernando |
| Provider affiliation | Physiology, University Zurich |
| Genetic information | Mice expressing cre recombinase under constitutive control of the mouse villin promoter, as well as two loxP sites inserted into intron 9 and exon 13 (the last one downstream the stop codon) of Slc34a2, the gene encoding the sodium/phosphate cotransporter NaPi-IIb. |
| Phenotypic information | Homozygous:Increased fecal excretion of phosphate and reduced urinary excretion of phosphate.Heterozygous:No phenotype. |
| Breeding history | Homozygous mice breed normally, 1 backcross to C57BL/6J. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6.129 |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Pulmonary alveolar microlithiasis / Orphanet_60025
Literature references
- Intestinal Depletion of NaPi-IIb/Slc34a2 in Mice: Renal and Hormonal Adaptation.;Hernando Nati, Myakala Komuraiah, Simona Fabia, Knöpfel Thomas, Thomas Linto, Murer Heini, Wagner Carsten A, Biber Jürg, ;2015;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;30;1925-37; 25827490