STOCK Slc34a2tm-Nhch Tg(Vil1-cre)20Syr/Orl
| Status | Available to order |
| EMMA ID | EM:15297 |
| Citation information | RRID:IMSR_EM:15297 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Slc34a2tm-Nhch Tg(Vil1-cre)20Syr/Orl |
| Alternative name | B6N.Cg-Tg(Vil1-cre)20Syr/J (#033019) x B6;129-Slc34a2 tm1Nhch; Short name: NaPillb-villin |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Slc34a2tm-Nhch, Tg(Vil1-cre)20Syr |
| Gene/Transgene symbol | Slc34a2, Tg(Vil1-cre)20Syr |
Information from provider
| Provider | Nati Hernando |
| Provider affiliation | Physiology, University Zurich |
| Genetic information | Mice expressing cre recombinase under constitutive control of the mouse villin promoter, as well as two loxP sites inserted into intron 9 and exon 13 (the last one downstream the stop codon) of Slc34a2, the gene encoding the sodium/phosphate cotransporter NaPi-IIb. |
| Phenotypic information | Homozygous:Increased fecal excretion of phosphate and reduced urinary excretion of phosphate.Heterozygous:No phenotype. |
| Breeding history | Homozygous mice breed normally, 1 backcross to C57BL/6J. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6.129 males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Pulmonary alveolar microlithiasis / Orphanet_60025
Literature references
- Intestinal Depletion of NaPi-IIb/Slc34a2 in Mice: Renal and Hormonal Adaptation.;Hernando Nati, Myakala Komuraiah, Simona Fabia, Knöpfel Thomas, Thomas Linto, Murer Heini, Wagner Carsten A, Biber Jürg, ;2015;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;30;1925-37; 25827490