B6Brd;B6N-Tyr^c-Brd Dscc1^{tm1a(KOMP)Wtsi}/WtsiOrl

Status	Available to order
EMMA ID	EM:15227
International strain name	B6Brd;B6N-Tyr^c-Brd Dscc1^{tm1a(KOMP)Wtsi}/WtsiOrl
Alternative name	EPD0064_2_H09
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Dscc1^{tm1a(KOMP)Wtsi}
Gene/Transgene symbol	Dscc1
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from KOMP ES clone EPD0064_2_H09. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.;White Jacqueline K, Gerdin Anna-Karin, Karp Natasha A, Ryder Ed, Buljan Marija, Bussell James N, Salisbury Jennifer, Clare Simon, Ingham Neil J, Podrini Christine, Houghton Richard, Estabel Jeanne, Bottomley Joanna R, Melvin David G, Sunter David, Adams Niels C, null null, Tannahill David, Logan Darren W, Macarthur Daniel G, Flint Jonathan, Mahajan Vinit B, Tsang Stephen H, Smyth Ian, Watt Fiona M, Skarnes William C, Dougan Gordon, Adams David J, Ramirez-Solis Ramiro, Bradley Allan, Steel Karen P, ;2013;Cell;154;452-64; 23870131

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

IMPC phenotypes (allele matching)

increased bone mineral density / IMPC
abnormal rib morphology / IMPC
decreased circulating LDL cholesterol level / IMPC
decreased circulating HDL cholesterol level / IMPC
increased lean body mass / IMPC
vertebral fusion / IMPC
increased lumbar vertebrae number / IMPC
abnormal behavior / IMPC
decreased circulating cholesterol level / IMPC
increased blood urea nitrogen level / IMPC
increased bone mineral content / IMPC
preweaning lethality, incomplete penetrance / IMPC

IMPC phenotypes (gene matching)

increased lumbar vertebrae number / IMPC
decreased circulating cholesterol level / IMPC
abnormal behavior / IMPC
increased lean body mass / IMPC
increased bone mineral content / IMPC
preweaning lethality, incomplete penetrance / IMPC
decreased circulating LDL cholesterol level / IMPC
vertebral fusion / IMPC
increased blood urea nitrogen level / IMPC
increased bone mineral density / IMPC
abnormal rib morphology / IMPC
decreased circulating HDL cholesterol level / IMPC

MGI phenotypes (allele matching)

increased bone mineral density / MGI
increased lean body mass / MGI
abnormal behavior / MGI
increased bone mineral content / MGI
abnormal rib morphology / MGI
increased rib number / MGI
vertebral fusion / MGI
decreased lumbar vertebrae number / MGI
increased thoracic vertebrae number / MGI
increased blood urea nitrogen level / MGI
increased sacral vertebrae number / MGI

MGI phenotypes (gene matching)

increased bone mineral density / MGI
abnormal rib morphology / MGI
increased rib number / MGI
increased lean body mass / MGI
vertebral fusion / MGI
decreased lumbar vertebrae number / MGI
increased thoracic vertebrae number / MGI
abnormal behavior / MGI
increased blood urea nitrogen level / MGI
increased sacral vertebrae number / MGI
increased bone mineral content / MGI

Literature references

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.;White Jacqueline K, Gerdin Anna-Karin, Karp Natasha A, Ryder Ed, Buljan Marija, Bussell James N, Salisbury Jennifer, Clare Simon, Ingham Neil J, Podrini Christine, Houghton Richard, Estabel Jeanne, Bottomley Joanna R, Melvin David G, Sunter David, Adams Niels C, null null, Tannahill David, Logan Darren W, Macarthur Daniel G, Flint Jonathan, Mahajan Vinit B, Tsang Stephen H, Smyth Ian, Watt Fiona M, Skarnes William C, Dougan Gordon, Adams David J, Ramirez-Solis Ramiro, Bradley Allan, Steel Karen P, ;2013;Cell;154;452-64; 23870131

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.

B6Brd;B6N-Tyrc-Brd Dscc1tm1a(KOMP)Wtsi/WtsiOrl