IMPC phenotypes (gene matching)
B6.129P2-Uhrf1Gt(XL796)Byg/Cnrm
| Status | Available to order |
| EMMA ID | EM:01518 |
| Citation information | RRID:IMSR_EM:01518 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Uhrf1Gt(XL796)Byg/Cnrm |
| Alternative name | Np95 gt |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Uhrf1Gt(XL796)Byg |
| Gene/Transgene symbol | Uhrf1 |
Information from provider
| Provider | Nina Offenhäuser |
| Provider affiliation | ifom |
| Genetic information | Insertion of the pGT0Lxf genetrap vector into the first intron of Uhrf1 (Np95) at 1200 bp 5' of the second coding exon. The XL796 ES cell line used to derive the mice was obtained from BayGenomics. |
| Phenotypic information | Embryonic lethal around 8.5dpc, possibly turning defect. |
| Breeding history | E14 ES cells were used to generate the mice, which were backcrossed for 5 generations to C57BL/6. Line kept as a backcross since homozygous mice are not viable. Out of 100 pups born from heterozygous x heterozygous cross there was no homozygous mutant. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal mesoderm development / MGI
- abnormal allantois morphology / MGI
- embryonic growth arrest / MGI
- abnormal nervous system morphology / MGI
- abnormal neural tube closure / MGI
- embryonic growth retardation / MGI
- abnormal sclerotome morphology / MGI
- small pharyngeal arch / MGI
- abnormal DNA methylation / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
Literature references
- Np95 is a histone-binding protein endowed with ubiquitin ligase activity.;Citterio Elisabetta, Papait Roberto, Nicassio Francesco, Vecchi Manuela, Gomiero Paola, Mantovani Roberto, Di Fiore Pier Paolo, Bonapace Ian Marc, ;2004;Molecular and cellular biology;24;2526-35; 14993289
- Targeted disruption of Np95 gene renders murine embryonic stem cells hypersensitive to DNA damaging agents and DNA replication blocks.;Muto Masahiro, Kanari Yasuyoshi, Kubo Eiko, Takabe Tamami, Kurihara Takayuki, Fujimori Akira, Tatsumi Kouichi, ;2002;The Journal of biological chemistry;277;34549-55; 12084726
- Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry.;Bonapace Ian Marc, Latella Lucia, Papait Roberto, Nicassio Francesco, Sacco Alessandra, Muto Masahiro, Crescenzi Marco, Di Fiore Pier Paolo, ;2002;The Journal of cell biology;157;909-14; 12058012
- Dynamic changes in subnuclear NP95 location during the cell cycle and its spatial relationship with DNA replication foci.;Miura M, Watanabe H, Sasaki T, Tatsumi K, Muto M, ;2001;Experimental cell research;263;202-8; 11161719
- Temporal and spatial localization of novel nuclear protein NP95 in mitotic and meiotic cells.;Uemura T, Kubo E, Kanari Y, Ikemura T, Tatsumi K, Muto M, ;2000;Cell structure and function;25;149-59; 10984098
- Cloning and mapping of Np95 gene which encodes a novel nuclear protein associated with cell proliferation.;Fujimori A, Matsuda Y, Takemoto Y, Hashimoto Y, Kubo E, Araki R, Fukumura R, Mita K, Tatsumi K, Muto M, ;1998;Mammalian genome : official journal of the International Mammalian Genome Society;9;1032-5; 9880673