IMPC phenotypes (gene matching)
- hyperplasia / IMPC
C57BL/6NCrl-Trex1em1(IMPC)Ccpcz/Ph
| Status | Under development - register interest |
| EMMA ID | EM:15160 |
| Citation information | RRID:IMSR_EM:15160 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NCrl-Trex1em1(IMPC)Ccpcz/Ph |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Trex1em1(IMPC)Ccpcz |
| Gene/Transgene symbol | Trex1 |
Information from provider
| Provider | Institute of Molecular Genetics |
| Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial Chilblain lupus / Orphanet_481662
- Aicardi-Goutières syndrome / Orphanet_51
- Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations / Orphanet_247691
MGI phenotypes (gene matching)
- abnormal heart morphology / MGI
- enlarged heart / MGI
- abnormal myocardial fiber morphology / MGI
- folliculitis / MGI
- lymphoid hyperplasia / MGI
- enlarged spleen / MGI
- enlarged lymph nodes / MGI
- thymus cortex hypoplasia / MGI
- atelectasis / MGI
- dermatitis / MGI
- skin lesions / MGI
- hepatic necrosis / MGI
- abnormal T cell activation / MGI
- increased inflammatory response / MGI
- heart inflammation / MGI
- abnormal atrial thrombosis / MGI
- myocarditis / MGI
- kidney inflammation / MGI
- lung inflammation / MGI
- vasculitis / MGI
- pancreas inflammation / MGI
- salivary gland inflammation / MGI
- stomach inflammation / MGI
- decreased litter size / MGI
- premature death / MGI
- abnormal kidney morphology / MGI
- abnormal spleen marginal zone morphology / MGI
- increased IgG level / MGI
- abnormal immune system organ morphology / MGI
- glomerulonephritis / MGI
- dilated heart atrium / MGI
- cardiac fibrosis / MGI
- increased autoantibody level / MGI
- renal necrosis / MGI
- myositis / MGI
- myocardial fiber degeneration / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- increased susceptibility to systemic lupus erythematosus / MGI
- skin inflammation / MGI
- increased spleen weight / MGI
- increased regulatory T cell number / MGI
- increased B cell number / MGI
- cardiomyopathy / MGI
- increased susceptibility to autoimmune disorder / MGI
- immune system phenotype / MGI
- congestive heart failure / MGI
- dilated heart ventricle / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased plasma cell number / MGI
- abnormal spleen B cell follicle morphology / MGI
- abnormal interferon secretion / MGI
- lacrimal gland inflammation / MGI
- increased splenocyte number / MGI
- liver vascular congestion / MGI
- tubulointerstitial nephritis / MGI
- renal glomerular immunoglobulin deposits / MGI