IMPC phenotypes (gene matching)
- hyperplasia / IMPC
C57BL/6NCrl-Trex1em1(IMPC)Ccpcz/Ph
| Status | Under development - register interest |
| EMMA ID | EM:15160 |
| International strain name | C57BL/6NCrl-Trex1em1(IMPC)Ccpcz/Ph |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Trex1em1(IMPC)Ccpcz |
| Gene/Transgene symbol | Trex1 |
Information from provider
| Provider | Institute of Molecular Genetics |
| Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial Chilblain lupus / Orphanet_481662
- Aicardi-Goutières syndrome / Orphanet_51
- Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations / Orphanet_247691
MGI phenotypes (gene matching)
- abnormal heart morphology / MGI
- enlarged heart / MGI
- abnormal myocardial fiber morphology / MGI
- folliculitis / MGI
- lymphoid hyperplasia / MGI
- enlarged spleen / MGI
- enlarged lymph nodes / MGI
- thymus cortex hypoplasia / MGI
- atelectasis / MGI
- dermatitis / MGI
- skin lesions / MGI
- hepatic necrosis / MGI
- abnormal T cell activation / MGI
- increased inflammatory response / MGI
- heart inflammation / MGI
- abnormal atrial thrombosis / MGI
- myocarditis / MGI
- kidney inflammation / MGI
- lung inflammation / MGI
- vasculitis / MGI
- pancreas inflammation / MGI
- salivary gland inflammation / MGI
- stomach inflammation / MGI
- decreased litter size / MGI
- premature death / MGI
- abnormal kidney morphology / MGI
- abnormal spleen marginal zone morphology / MGI
- increased IgG level / MGI
- abnormal immune system organ morphology / MGI
- glomerulonephritis / MGI
- dilated heart atrium / MGI
- cardiac fibrosis / MGI
- increased autoantibody level / MGI
- renal necrosis / MGI
- myositis / MGI
- myocardial fiber degeneration / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- increased susceptibility to systemic lupus erythematosus / MGI
- skin inflammation / MGI
- increased spleen weight / MGI
- increased regulatory T cell number / MGI
- increased B cell number / MGI
- cardiomyopathy / MGI
- increased susceptibility to autoimmune disorder / MGI
- immune system phenotype / MGI
- congestive heart failure / MGI
- dilated heart ventricle / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased plasma cell number / MGI
- abnormal spleen B cell follicle morphology / MGI
- abnormal interferon secretion / MGI
- lacrimal gland inflammation / MGI
- increased splenocyte number / MGI
- liver vascular congestion / MGI
- tubulointerstitial nephritis / MGI
- renal glomerular immunoglobulin deposits / MGI