B6.129S2-BicralGt(M019E03)Wrst/Cnrm

Status

Available to order

EMMA IDEM:01516
Citation informationRRID:IMSR_EM:01516 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.129S2-BicralGt(M019E03)Wrst/Cnrm
Alternative nameM019E03
Strain typeGene-trap
Allele/Transgene symbolBicralGt(M019E03)Wrst
Gene/Transgene symbolBicral

Information from provider

ProviderHarald von Melchner
Provider affiliationUniversity of Frankfurt Medical School
Genetic informationDisruption of intron 5 of the Bicral gene (or Gltscr1l, glioma tumor suppressor candidate region gene 1-like; synonyms: BC032203, KIAA0240) by the U3bgeo retroviral gene trap vector.
Phenotypic informationEmbryonic lethal (E9.5), growth retarded, turning defect, hypertrophic heart.
Breeding historyBackcrossed over 5 generations.
References
  • A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.;Hansen Jens, Floss Thomas, Van Sloun Petra, Füchtbauer Ernst-Martin, Vauti Franz, Arnold Hans-Hennig, Schnütgen Frank, Wurst Wolfgang, von Melchner Harald, Ruiz Patricia, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;9918-22; 12904583

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased prepulse inhibition / IMPC
  • male infertility / IMPC
  • increased startle reflex / IMPC
  • decreased bone mineral content / IMPC
  • increased blood urea nitrogen level / IMPC
  • increased mean corpuscular volume / IMPC
  • abnormal retina morphology / IMPC
  • increased total body fat amount / IMPC
  • abnormal bone structure / IMPC
  • decreased lean body mass / IMPC
  • decreased bone mineral density / IMPC
  • increased mean corpuscular hemoglobin / IMPC
MGI phenotypes (allele matching)
  • cardiac hypertrophy / MGI
  • abnormal embryo turning / MGI
  • embryonic growth retardation / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
MGI phenotypes (gene matching)
  • cardiac hypertrophy / MGI
  • abnormal embryo turning / MGI
  • embryonic growth retardation / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI

Literature references

  • A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.;Hansen Jens, Floss Thomas, Van Sloun Petra, Füchtbauer Ernst-Martin, Vauti Franz, Arnold Hans-Hennig, Schnütgen Frank, Wurst Wolfgang, von Melchner Harald, Ruiz Patricia, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;9918-22; 12904583

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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