- decreased prepulse inhibition / IMPC
- male infertility / IMPC
- increased startle reflex / IMPC
- decreased bone mineral content / IMPC
- increased blood urea nitrogen level / IMPC
- increased mean corpuscular volume / IMPC
- abnormal retina morphology / IMPC
- increased total body fat amount / IMPC
- abnormal bone structure / IMPC
- decreased lean body mass / IMPC
- decreased bone mineral density / IMPC
- increased mean corpuscular hemoglobin / IMPC
B6.129S2-BicralGt(M019E03)Wrst/Cnrm
Status | Available to order |
EMMA ID | EM:01516 |
International strain name | B6.129S2-BicralGt(M019E03)Wrst/Cnrm |
Alternative name | M019E03 |
Strain type | Gene-trap |
Allele/Transgene symbol | BicralGt(M019E03)Wrst |
Gene/Transgene symbol | Bicral |
Information from provider
Provider | Harald von Melchner |
Provider affiliation | University of Frankfurt Medical School |
Genetic information | Disruption of intron 5 of the Bicral gene (or Gltscr1l, glioma tumor suppressor candidate region gene 1-like; synonyms: BC032203, KIAA0240) by the U3bgeo retroviral gene trap vector. |
Phenotypic information | Embryonic lethal (E9.5), growth retarded, turning defect, hypertrophic heart. |
Breeding history | Backcrossed over 5 generations. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
IMPC phenotypes (gene matching)
Literature references
- A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.;Hansen Jens, Floss Thomas, Van Sloun Petra, Füchtbauer Ernst-Martin, Vauti Franz, Arnold Hans-Hennig, Schnütgen Frank, Wurst Wolfgang, von Melchner Harald, Ruiz Patricia, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;9918-22; 12904583
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