| Status | Available to order |
| EMMA ID | EM:15139 |
| Citation information | RRID:IMSR_EM:15139 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6J.Cg-Pik3c2atm1Ehi/Cnrm |
| Alternative name | PI3KC2A-LacZ |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Pik3c2atm1Ehi |
| Gene/Transgene symbol | Pik3c2a |
| Provider | Emilio Hirsch |
| Provider affiliation | University of Torino |
| Genetic information | A lacZ (bacterial beta-galactosidase)-neoR cassette was inserted in-frame with the ATG start codon of Pik3c2a via bacterial recombination. Constructs were electroporated in embryonic stem cells and chimeras obtained by standard procedures. |
| Phenotypic information | Homozygous:Loss of the Pik3c2a gene in mouse has been reported to cause early embryonic lethality, initially ascribed to defective vasculogenesis (Yoshioka et al., Nat. Med., 2012, 18:1560–1569).Heterozygous:Heterozygous mice do not display abnormalities and are viable and fertile. |
| Breeding history | Mice were backcrossed for 8 generations to the C57BL/6J background. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
