IMPC phenotypes (gene matching)
C57BL/6NTac-Appem1H/H
| Status | Available to order |
| EMMA ID | EM:15124 |
| Citation information | RRID:IMSR_EM:15124 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NTac-Appem1H/H |
| Alternative name | APP-MABH-EM1-B6N |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Appem1H |
| Gene/Transgene symbol | App |
Information from provider
| Provider | MRC-Harwell |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
| Breeding history | Co-isogenic on original background |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- ABeta amyloidosis, Italian type / Orphanet_324713
- ABetaL34V amyloidosis / Orphanet_324703
- ABeta amyloidosis, Arctic type / Orphanet_324723
- ABetaA21G amyloidosis / Orphanet_324718
- ABeta amyloidosis, Dutch type / Orphanet_100006
- ABeta amyloidosis, Iowa type / Orphanet_324708
- Early-onset autosomal dominant Alzheimer disease / Orphanet_1020
MGI phenotypes (gene matching)
- amyloidosis / MGI
- muscle degeneration / MGI
- decreased corpus callosum size / MGI
- abnormal telencephalon morphology / MGI
- decreased body weight / MGI
- increased anxiety-related response / MGI
- abnormal locomotor behavior / MGI
- hyperactivity / MGI
- hypoactivity / MGI
- decreased exploration in new environment / MGI
- abnormal cued conditioning behavior / MGI
- abnormal spatial learning / MGI
- reduced long term potentiation / MGI
- impaired swimming / MGI
- intracerebral hemorrhage / MGI
- abnormal learning/memory/conditioning / MGI
- abnormal fear/anxiety-related behavior / MGI
- abnormal motor capabilities/coordination/movement / MGI
- premature death / MGI
- abnormal brain morphology / MGI
- no abnormal phenotype detected / MGI
- decreased brain weight / MGI
- gliosis / MGI
- absent corpus callosum / MGI
- abnormal brain commissure morphology / MGI
- abnormal long term potentiation / MGI
- abnormal emotion/affect behavior / MGI
- increased thigmotaxis / MGI
- abnormal active avoidance behavior / MGI
- abnormal long term object recognition memory / MGI
- abnormal neuron morphology / MGI
- no phenotypic analysis / MGI
- abnormal locomotor activation / MGI
- amyloid beta deposits / MGI
- astrocytosis / MGI
- nervous system phenotype / MGI
- impaired passive avoidance behavior / MGI
- myositis / MGI
- homeostasis/metabolism phenotype / MGI
- growth/size/body region phenotype / MGI
- behavior/neurological phenotype / MGI
- abnormal cell physiology / MGI
- decreased hippocampal commissure size / MGI
- decreased anterior commissure size / MGI
- abnormal spatial reference memory / MGI
- hematoma / MGI
- microgliosis / MGI
- increased variability of skeletal muscle fiber size / MGI
- centrally nucleated skeletal muscle fibers / MGI
- abnormal synapse morphology / MGI
- decreased grip strength / MGI
- altered susceptibility to induced thrombosis / MGI
- abnormal circadian behavior / MGI