IMPC phenotypes (gene matching)
C57BL/6NTac-Casrem1H/H
| Status | Available to order |
| EMMA ID | EM:15119 |
| International strain name | C57BL/6NTac-Casrem1H/H |
| Alternative name | CASR-MSCARLET-EM1-B6N |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Casrem1H |
| Gene/Transgene symbol | Casr |
Information from provider
| Provider | MRC-Harwell |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
| Breeding history | Co-isogenic on original background |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Neonatal severe primary hyperparathyroidism / Orphanet_417
- Familial hypocalciuric hypercalcemia type 1 / Orphanet_93372
- Autosomal dominant hypocalcemia / Orphanet_428
MGI phenotypes (gene matching)
- delayed bone ossification / MGI
- decreased bone mineral density / MGI
- kyphoscoliosis / MGI
- increased circulating calcium level / MGI
- decreased circulating calcium level / MGI
- decreased circulating phosphate level / MGI
- decreased body weight / MGI
- decreased body size / MGI
- cataract / MGI
- dehydration / MGI
- aphagia / MGI
- abnormal posture / MGI
- increased circulating phosphate level / MGI
- postnatal growth retardation / MGI
- abnormal coat/hair pigmentation / MGI
- premature death / MGI
- increased hematocrit / MGI
- abnormal bone mineralization / MGI
- decreased urine phosphate level / MGI
- increased circulating parathyroid hormone level / MGI
- decreased circulating parathyroid hormone level / MGI
- abnormal postural reflex / MGI
- decreased urine calcium level / MGI
- enlarged parathyroid gland / MGI
- pigmented parathyroid gland / MGI
- rickets / MGI
- calcinosis / MGI
- nephrocalcinosis / MGI
- calcified muscle / MGI
- increased width of hypertrophic chondrocyte zone / MGI
- parathyroid gland hyperplasia / MGI
- lethargy / MGI
- renal/urinary system phenotype / MGI
- growth/size/body region phenotype / MGI
- endocrine/exocrine gland phenotype / MGI
- skeleton phenotype / MGI
- hematopoietic system phenotype / MGI
- increased circulating magnesium level / MGI
- postnatal lethality, complete penetrance / MGI
- abnormal parathyroid gland chief cell morphology / MGI
- tongue inflammation / MGI