IMPC phenotypes (gene matching)
B6.Cg-Nfat5tm1.1Joar/Cnbc
| Status | Available to order |
| EMMA ID | EM:15109 |
| Citation information | RRID:IMSR_EM:15109 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Nfat5tm1.1Joar/Cnbc |
| Alternative name | NFAT5 floxed mice |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Nfat5tm1.1Joar |
| Gene/Transgene symbol | Nfat5 |
Information from provider
| Provider | Cristina Lopez Rodriguez |
| Provider affiliation | Universitat Pompeu Fabra |
| Genetic information | Exon 6 of the Nfat5 gene was flanked by loxP sites by homologous recombination in C57BL/6-derived embryonic stem cells (Bruce 4). Original reference: Drews-Elger et al. PLoS One, 2009. |
| Phenotypic information | Homozygous:No obvious phenotype unless immune responses are induced. The full Nfat5 knock-out is expected to be embryonic lethal in the C57BL/6 genetic background. Nfat5 floxed mice are healthy, with no phenotype. In our hands, conditional Nfat5 knock-outs in different immune cell subtypes are healthy. Heterozygous:No observed phenotype. |
| Breeding history | Mutant mice were generated by homologous recombination in C57BL/6-derived embryonic stem cells (Bruce 4) and performing several backcrosses (more than 10 generations) to C57BL/6. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Disease and phenotype information
Literature references
- The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress.;Drews-Elger Katherine, Ortells M Carmen, Rao Anjana, López-Rodriguez Cristina, Aramburu Jose, ;2009;PloS one;4;e5245; 19381288
- NFAT5 Controls the Integrity of Epidermis.;Muhammad Khalid, Xavier Delicia, Klein-Hessling Stefan, Azeem Muhammad, Rauschenberger Tabea, Murti Krisna, Avots Andris, Goebeler Matthias, Klein Matthias, Bopp Tobias, Sielaff Malte, Tenzer Stefan, Möckel Sigrid, Aramburu José, López-Rodríguez Cristina, Kerstan Andreas, Serfling Edgar, ;2021;Frontiers in immunology;12;780727; 34956208
- Salt-Sensitive Hypertension of the Renal Tubular Cell-Specific NFAT5 (Nuclear Factor of Activated T-Cells 5) Knockout Mice.;Hiramatsu Akiko, Izumi Yuichiro, Eguchi Koji, Matsuo Naomi, Deng Qinyuan, Inoue Hideki, Nakayama Yushi, Nonoguchi Hiroshi, Aramburu Jose, López-Rodríguez Cristina, Kakizoe Yutaka, Adachi Masataka, Kuwabara Takashige, Kim-Mitsuyama Shokei, Mukoyama Masashi, ;2021;Hypertension (Dallas, Tex. : 1979);78;1335-1346; 34601973
- The transcription factor NFAT5 limits infection-induced type I interferon responses.;Huerga Encabo Hector, Traveset Laia, Argilaguet Jordi, Angulo Ana, Nistal-Villán Estanislao, Jaiswal Rahul, Escalante Carlos R, Gekas Christos, Meyerhans Andreas, Aramburu Jose, López-Rodríguez Cristina, ;2020;The Journal of experimental medicine;217;2901-2918; 31816635
- Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5.;Buxadé Maria, Huerga Encabo Hector, Riera-Borrull Marta, Quintana-Gallardo Lucía, López-Cotarelo Pilar, Tellechea Mónica, Martínez-Martínez Sara, Redondo Juan Miguel, Martín-Caballero Juan, Flores Juana María, Bosch Elena, Rodríguez-Fernández José Luis, Aramburu Jose, López-Rodríguez Cristina, ;2018;The Journal of experimental medicine;215;101; 30327417
- Analgesia linked to Nav1.7 loss of function requires µ- and δ-opioid receptors.;Pereira Vanessa, Millet Queensta, Aramburu Jose, Lopez-Rodriguez Cristina, Gaveriaux-Ruff Claire, Wood John N, ;2018;Wellcome open research;3;305-315; 30271888
- NFAT5-Regulated Macrophage Polarization Supports the Proinflammatory Function of Macrophages and T Lymphocytes.;Tellechea Mónica, Buxadé Maria, Tejedor Sonia, Aramburu Jose, López-Rodríguez Cristina, ;2018;Journal of immunology (Baltimore, Md. : 1950);200;56-67; 29150563
- Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5.;Alberdi Maria, Iglesias Marcos, Tejedor Sonia, Merino Ramón, López-Rodríguez Cristina, Aramburu Jose, ;2017;Immunology and cell biology;95;; 27479742