STOCK Ts(1716)66Yah/Ics
| Status | Available to order |
| EMMA ID | EM:15096 |
| Citation information | RRID:IMSR_EM:15096 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Ts(1716)66Yah/Ics |
| Alternative name | B6C3B Ts66Yah |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Ts(1716)66Yah |
| Gene/Transgene symbol | Ts(17<16>)66Yah |
Information from provider
| Provider | Yann HERAULT |
| Provider affiliation | CERBM GIE |
| Genetic information | An upgraded Down syndrome model, carrying a segregating mini-chromosome, trisomic for a region encompassing the Mir155 to Zbtb21 genes homologous to human chromosome 21 and linked to the centromeric region of mouse chromosome 17 with no genes. |
| Phenotypic information | Homozygous:Not available.Heterozygous:Changes in behaviour and cognition, craniofacial phenotypes and hippocampal gene expression observed in trisomic individuals. |
| Breeding history | Kept in an F1 B6C3B genetic background, with the C57BL/6J and the C3B line as a C3H/HeN congenic line for the BALB/c allele at the Pde6b locus (Hart et al., 2005; Hoelter et al., 2008). |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
MGI allele-associated human disease models
Literature references
- Ts66Yah, a mouse model of Down syndrome with improved construct and face validity.;Duchon Arnaud, Del Mar Muñiz Moreno Maria, Chevalier Claire, Nalesso Valérie, Andre Philippe, Fructuoso-Castellar Marta, Mondino Mary, Po Chrystelle, Noblet Vincent, Birling Marie-Christine, Potier Marie-Claude, Herault Yann, ;2022;Disease models & mechanisms;15;; 36374158