- decreased mean corpuscular volume / IMPC
- increased bone mineral content / IMPC
- abnormal bone mineralization / IMPC
- decreased granulocyte number / IMPC
- decreased mean corpuscular hemoglobin concentration / IMPC
- abnormal bone structure / IMPC
- decreased circulating glucose level / IMPC
- increased circulating creatinine level / IMPC
- decreased heart weight / IMPC
C57BL/6N-Eif2b5tm1c(EUCOMM)Wtsi/IcsOrl
Status | Available to order |
EMMA ID | EM:15095 |
Citation information | RRID:IMSR_EM:15095 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | C57BL/6N-Eif2b5tm1c(EUCOMM)Wtsi/IcsOrl |
Alternative name | Eif2b5-tm1c(EUCOMM)Wtsi/IcsOrl |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Eif2b5tm1c(EUCOMM)Wtsi |
Gene/Transgene symbol | Eif2b5 |
Information from provider
Provider | Cécile FREMOND |
Provider affiliation | CNRS-TAAM-UAR44 |
Genetic information | This mouse line originates from EUCOMM ES clone EPD0116_1_C09. For further details on the construction of this clone see the description at the IMPC portal. |
Phenotypic information | Homozygous:Homozygous mice have not been generated.Heterozygous:Heterozygous mice are currently being generated. |
Breeding history | Rederived mice carrying the Eif2b5tm1a(EUCOMM)Wtsi mutation were crossed with the flp recombinase expressing strain C57BL/6NTac-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Ics (EMMA strain EM:05490) to obtain mice carrying the Eif2b5tm1c(EUCOMM)Wtsi converted allele. |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | heterozygous C57BL/6N males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Congenital or early infantile CACH syndrome / Orphanet_157713
- Late infantile CACH syndrome / Orphanet_157716
- Ovarioleukodystrophy / Orphanet_99853
- Juvenile or adult CACH syndrome / Orphanet_157719
- Cree leukoencephalopathy / Orphanet_99854
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal forebrain morphology / MGI
- abnormal myelination / MGI
- demyelination / MGI
- sporadic seizures / MGI
- decreased body weight / MGI
- abnormal retina morphology / MGI
- ataxia / MGI
- impaired coordination / MGI
- premature death / MGI
- abnormal astrocyte morphology / MGI
- ectopic Bergmann glia cells / MGI
- abnormal locomotor activation / MGI
- abnormal microglial cell physiology / MGI
- abnormal retinal outer nuclear layer morphology / MGI
- abnormal retinal inner nuclear layer morphology / MGI
- abnormal axon morphology / MGI
- decreased percent body fat/body weight / MGI
- brain vacuoles / MGI
- abnormal brain white matter morphology / MGI
- abnormal brain internal capsule morphology / MGI
- thin retinal inner plexiform layer / MGI
- abnormal physiological response to xenobiotic / MGI
- abnormal astrocyte physiology / MGI
- decreased oligodendrocyte number / MGI
- abnormal cerebellum white matter morphology / MGI
- decreased grip strength / MGI
- increased oligodendrocyte number / MGI
Information on how we integrate external resources can be found here
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