C57BL/6N-Eif2b5tm1c(EUCOMM)Wtsi/IcsOrl

Status

Available to order

EMMA IDEM:15095
International strain nameC57BL/6N-Eif2b5tm1c(EUCOMM)Wtsi/IcsOrl
Alternative nameEif2b5-tm1c(EUCOMM)Wtsi/IcsOrl
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolEif2b5tm1c(EUCOMM)Wtsi
Gene/Transgene symbolEif2b5

Information from provider

ProviderCécile FREMOND
Provider affiliationCNRS-TAAM-UAR44
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0116_1_C09. For further details on the construction of this clone see the description at the IMPC portal.
Phenotypic informationHomozygous:
Homozygous mice have not been generated.

Heterozygous:
Heterozygous mice are currently being generated.
Breeding historyRederived mice carrying the Eif2b5tm1a(EUCOMM)Wtsi mutation were crossed with the flp recombinase expressing strain C57BL/6NTac-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Ics (EMMA strain EM:05490) to obtain mice carrying the Eif2b5tm1c(EUCOMM)Wtsi converted allele.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6N

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased mean corpuscular volume / IMPC
  • increased bone mineral content / IMPC
  • abnormal bone mineralization / IMPC
  • decreased granulocyte number / IMPC
  • decreased mean corpuscular hemoglobin concentration / IMPC
  • abnormal bone structure / IMPC
  • decreased circulating glucose level / IMPC
  • increased circulating creatinine level / IMPC
  • decreased heart weight / IMPC
MGI phenotypes (gene matching)
  • abnormal forebrain morphology / MGI
  • abnormal myelination / MGI
  • demyelination / MGI
  • sporadic seizures / MGI
  • decreased body weight / MGI
  • abnormal retina morphology / MGI
  • ataxia / MGI
  • impaired coordination / MGI
  • premature death / MGI
  • abnormal astrocyte morphology / MGI
  • ectopic Bergmann glia cells / MGI
  • abnormal locomotor activation / MGI
  • abnormal microglial cell physiology / MGI
  • abnormal retinal outer nuclear layer morphology / MGI
  • abnormal retinal inner nuclear layer morphology / MGI
  • abnormal axon morphology / MGI
  • decreased percent body fat/body weight / MGI
  • brain vacuoles / MGI
  • abnormal brain white matter morphology / MGI
  • abnormal brain internal capsule morphology / MGI
  • thin retinal inner plexiform layer / MGI
  • abnormal physiological response to xenobiotic / MGI
  • abnormal astrocyte physiology / MGI
  • decreased oligodendrocyte number / MGI
  • abnormal cerebellum white matter morphology / MGI
  • decreased grip strength / MGI
  • increased oligodendrocyte number / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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