- decreased mean corpuscular volume / IMPC
- increased bone mineral content / IMPC
- abnormal bone mineralization / IMPC
- decreased granulocyte number / IMPC
- decreased mean corpuscular hemoglobin concentration / IMPC
- abnormal bone structure / IMPC
- decreased circulating glucose level / IMPC
- increased circulating creatinine level / IMPC
- decreased heart weight / IMPC
C57BL/6N-Eif2b5tm1c(EUCOMM)Wtsi/IcsOrl
Status | Available to order |
EMMA ID | EM:15095 |
International strain name | C57BL/6N-Eif2b5tm1c(EUCOMM)Wtsi/IcsOrl |
Alternative name | Eif2b5-tm1c(EUCOMM)Wtsi/IcsOrl |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Eif2b5tm1c(EUCOMM)Wtsi |
Gene/Transgene symbol | Eif2b5 |
Information from provider
Provider | Cécile FREMOND |
Provider affiliation | CNRS-TAAM-UAR44 |
Genetic information | This mouse line originates from EUCOMM ES clone EPD0116_1_C09. For further details on the construction of this clone see the description at the IMPC portal. |
Phenotypic information | Homozygous:Homozygous mice have not been generated.Heterozygous:Heterozygous mice are currently being generated. |
Breeding history | Rederived mice carrying the Eif2b5tm1a(EUCOMM)Wtsi mutation were crossed with the flp recombinase expressing strain C57BL/6NTac-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Ics (EMMA strain EM:05490) to obtain mice carrying the Eif2b5tm1c(EUCOMM)Wtsi converted allele. |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | heterozygous C57BL/6N |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Congenital or early infantile CACH syndrome / Orphanet_157713
- Late infantile CACH syndrome / Orphanet_157716
- Ovarioleukodystrophy / Orphanet_99853
- Juvenile or adult CACH syndrome / Orphanet_157719
- Cree leukoencephalopathy / Orphanet_99854
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal forebrain morphology / MGI
- abnormal myelination / MGI
- demyelination / MGI
- sporadic seizures / MGI
- decreased body weight / MGI
- abnormal retina morphology / MGI
- ataxia / MGI
- impaired coordination / MGI
- premature death / MGI
- abnormal astrocyte morphology / MGI
- ectopic Bergmann glia cells / MGI
- abnormal locomotor activation / MGI
- abnormal microglial cell physiology / MGI
- abnormal retinal outer nuclear layer morphology / MGI
- abnormal retinal inner nuclear layer morphology / MGI
- abnormal axon morphology / MGI
- decreased percent body fat/body weight / MGI
- brain vacuoles / MGI
- abnormal brain white matter morphology / MGI
- abnormal brain internal capsule morphology / MGI
- thin retinal inner plexiform layer / MGI
- abnormal physiological response to xenobiotic / MGI
- abnormal astrocyte physiology / MGI
- decreased oligodendrocyte number / MGI
- abnormal cerebellum white matter morphology / MGI
- decreased grip strength / MGI
- increased oligodendrocyte number / MGI
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).